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2015-07-28

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cc by-nc-nd (c) European Society of Clinical Microbiology and Infectious Diseases, 2015
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/99513

High prevalence of Pneumocystis jirovecii pneumonia among Mozambican children < 5 years of age admitted to hospital with clinical severe pneumonia

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http://dx.doi.org/10.1016/j.cmi.2015.07.011

Resum

We aimed to describe Pneumocystis jirovecii pneumonia (PCP) prevalence and features in children from sub-Saharan Africa, and to investigate PCP-associated risk factors. During 2006-2007 we used molecular methods to test children younger than 5 years old admitted with severe pneumonia to a hospital in Southern Mozambique for Pneumocystis infection. We recruited 834 children. PCP prevalence was 6.8% and HIV prevalence was 25.7%. The in-hospital and delayed mortality were significantly higher among children with PCP (20.8% vs. 10.2 %, p=0.021, and 11.5% vs. 3.6%, p=0.044, respectively). Clinical features were mostly overlapping between the two groups. Independent risk factors for PCP were age less than a year (OR 6.34, 95%CI 1.86-21.65), HIV infection (OR 2.99, 95%CI 1.16-7.70), grunting (OR 2.64, 95%CI 1.04-6.73), and digital clubbing (OR 10.75, 95%CI 1.21-95.56). PCP is a common and life-threatening cause of severe pneumonia in Mozambican children. Mother-to-child HIV transmission prevention should be strengthened. Better diagnostic tools are needed.

Matèries

Pneumònia, Infants

Matèries (anglès)

Pneumonia, Children

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Articles publicats en revistes (ISGlobal)

Citació

LANASPA, Miguel, O'CALLAGHAN GORDO, Cristina, MACHEVO, Sonia, MADRID, Lola, NHAMPOSSA, Tacilta, ACÁCIO, Sozinho, HORRA, C. de la, FRIAZA, Vicente, CAMPANO, E., ALONSO, Pedro, CALDERON, Enrique j., ROCA, A., BASSAT ORELLANA, Quique. High prevalence of Pneumocystis jirovecii pneumonia among
                Mozambican children < 5 years of age admitted to hospital
                with clinical severe pneumonia. _Clinical Microbiology and Infection_. 2015. Vol. 21, núm. 11, pàgs. 1018. [consulta: 11 de abril de 2026]. ISSN: 1198-743X. [Disponible a: https://hdl.handle.net/2445/99513]

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