Carregant...
Tipus de document
ArticleData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/174540
Exploiting metabolic vulnerabilities of Non small cell lung carcinoma
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Lung cancer is the main cause of cancer death worldwide. Non-Small Cell Lung Carcinoma (NSCLC) is the most common subtype of lung cancer, and the prognosis of NSCLC patients in advanced stages is still very poor. Given the need for new therapies, the metabolism of NSCLC has been widely studied in the past two decades to identify vulnerabilities that could be translated into novel anti-metabolic therapeutic approaches. A number of studies have highlighted the role of glucose and mitochondrial metabolism in the development of NSCLC. The metabolic properties of lung tumors have been characterized in detail in vivo, and they include high glucose and lactate use and high heterogeneity regarding the use of nutrients and mitochondrial pathways. This heterogeneity has also been observed in patients infused with labeled nutrients. We will summarize here the knowledge about the use of amino acids, fatty acids and carbohydrates in NSCLC that could lead to new combination treatments.
Matèries
Matèries (anglès)
Citació
Citació
MAJEM, Blanca, NADAL, Ernest, MUÑOZ PINEDO, Cristina. Exploiting metabolic vulnerabilities of Non small cell lung carcinoma. _Seminars in Cell & Developmental Biology_. 2020. Vol. 98, núm. 54-62. [consulta: 21 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/174540]