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2013-05-24

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cc-by (c) Riggio et al., 2013
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/69448

Generation of magnetized olfactory ensheathing cells for regenerative studies in the central and peripheral nervous tissue

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As olfactory receptor axons grow from the peripheral to the central nervous system (CNS) aided by olfactory ensheathing cells (OECs), the transplantation of OECs has been suggested as a plausible therapy for spinal cord lesions. The problem with this hypothesis is that OECs do not represent a single homogeneous entity, but, instead, a functionally heterogeneous population that exhibits a variety of responses, including adhesion and repulsion during cell-matrix interactions. Some studies report that the migratory properties of OECs are compromised by inhibitory molecules and potentiated by chemical gradients. In this paper, we report a system based on modified OECs carrying magnetic nanoparticles as a proof of concept experiment enabling specific studies aimed at exploring the potential of OECs in the treatment of spinal cord injuries. Our studies have confirmed that magnetized OECs (i) survive well without exhibiting stress-associated cellular responses; (ii) in vitro, their migration can be modulated by magnetic fields; and (iii) their transplantation in organotypic slices of spinal cord and peripheral nerve showed positive integration in the model. Altogether, these findings indicate the therapeutic potential of magnetized OECs for CNS injuries.

Recurs relacionat

http://dx.doi.org/10.3390/ijms140610852

Matèries

Regeneració del sistema nerviós, Neuròglia, Medul·la espinal

Matèries (anglès)

Nervous system regeneration, Neuroglia, Spinal cord

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Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

Citació

RIGGIO, Cristina, et al. Generation of magnetized olfactory ensheathing cells for regenerative studies in the central and peripheral nervous tissue. International Journal of Molecular Sciences. 2013. Vol. 14, num. 6, pags. 10852-10868. ISSN 1422-0067. [consulted: 14 of November of 2026]. Available at: https://hdl.handle.net/2445/69448

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