Comunicacions a congressos (Genètica, Microbiologia i Estadística)

Permanent URI for this collectionhttps://hdl.handle.net/2445/12554

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Active wetting of epithelial tissues.
(American Society for Cell Biology, 2017-12-01) Pérez González, Carlos; Alert Zenón, Ricard; Blanch Mercader, Carles; Gómez González, Manuel; Kolodziej, Tomasz; Bazellières, Elsa; Casademunt i Viader, Jaume; Trepat Guixer, Xavier
Development, regeneration and cancer involve changes in cell mechanical properties that lead to drastic transitions in tissue geometry and dimensionality. Given the fluid nature of living tissues, these transitions have been experimentally studied and theoretically modelled in terms of the physics of wetting phenomena, which describes how a fluid droplet spreads on a solid surface. However, physical forces, the effective determinants of tissue spreading, have never been measured in the context of tissue wetting. Here we perform a systematic study of tissue mechanics during epithelial wetting/dewetting. We induce a progressive expression of E‐cadherin in a confined monolayer of MDA‐MB‐231 cells and, simultaneously, we measure tissue forces using Traction Force Microscopy and Monolayer Stress Microscopy. The gradual formation of intercellular junctions produces a continuous increase in tissue contractility (pMLC), triggering a two‐fold increase in tissue forces that ends up in a spontaneous wetting‐dewetting transition. To understand how this transition arises from tissue active properties, we develop a wetting model based on active gels theory. Combining theory and experiments, we find that wetting‐dewetting transition results from a competition between contractility and traction forces, which introduces a new length scale, defining a critical size for tissue wetting. Strikingly, this implies that the critical tissue contractility driving the transition is dependent on tissue size, a phenomenon that has no counterpart in passive wetting/dewetting physics. Furthermore, we find that the critical tractions, which depend linearly on substrate ligand density, are the mechanical threshold for tissue spreading. Finally, we show that long‐wavelength morphological instabilities in our fluid interface, together with active fluctuations, explain tissue shape dynamics during dewetting. We conclude that tissue spreading can be understood as an active wetting transition of a viscous polar fluid.
Pharmacological inhibition of soluble epoxide hydrolase protects cognitive impairment in a Niemann-Pick mice model
(2020-09) Companys Alemany, Júlia; Cozar, Mónica; Grinberg Vaisman, Daniel Raúl; Vilageliu i Arqués, Lluïsa; Codony Gisbert, Sandra; Vázquez Cruz, Santiago; Pallàs i Llibería, Mercè, 1964-; Griñán Ferré, Christian
Niemann-Pick type C (NPC) disease is a childhood autosomal recessive inherited rare neurodegenerative disease characterized by accumulation of cholesterol and glycosphingolipids and where the autophagy-lysosome system and inflammatory processes are implicated in the pathogenesis of the disease. We follow a novel approach to deal with NPC disease, by modulating key features of the disease such as inflammation and autophagy, through inhibition of soluble epoxide hydrolase (sEH).
Making sense of metabolomic data: comprehensive analysis of altered metabolic pathways in diabetes and obesity
(Universitat de Barcelona. Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), 2017-11-16) Palau Rodríguez, Magalí; Marco Ramell, Anna; Alay, Ania; Tulipani, Sara; Sànchez, Àlex (Sànchez Pla); Andrés Lacueva, Ma. Cristina
How to calculate number of samples in the design of pre/pro-biotics studies (metagenomic studies)
(Universitat de Barcelona. Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), 2017-11-16) Monleón Getino, Toni; Rodríguez Casado, Clara; Méndez Viera, Javier
Comparison of metagenomic profile of patients, meeting criteria for non-celiac gluten sensitivity, with and without response to restrictive diets
(Universitat de Barcelona. Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), 2017-11-16) Varas Lorenzo, Modesto José; Sánchez-Vizcaíno, E.; Monleón Getino, Toni
Lessons learnt from a norovirus outbreak caused by bottled mineral water
(Universitat de Barcelona. Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), 2017-11-16) Guix Arnau, Susana; Blanco Ortiz, Albert; Pintó Solé, Rosa María; Fuentes Pardo, Cristina; Rodríguez Garrido, V.; Alonso, M.; Bartolomé, B.; Cornejo Sánchez, Thais; Pumarola Suñé, Tomàs; Bosch, Albert
Microbial metabolites are associated with a high adherence to a Mediterranean dietary pattern using a 1H-NMR-based untargeted metabolomics approach [Congrés]
(Universitat de Barcelona. Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), 2017-11-16) Almanza Aguilera, Enrique; Urpí Sardà, Mireia; Llorach, Rafael; Vázquez Fresno, Rosa; Garcia Aloy, Mar; Carmona Pontaque, Francesc; Sànchez, Àlex (Sànchez Pla); Madrid Gambín, Francisco Javier; Estruch Riba, Ramon; Corella Piquer, Dolores; Andrés Lacueva, Ma. Cristina
Descripción de una ruta metabólica singular en Pseudomonas aeruginosa: síntesis de oxilipinas (Seminaris de Recerca 2017)
(Universitat de Barcelona. Facultat de Farmàcia, 2017-03-21) Estupiñán Romero, Mónica
Gens, gènere i ciència
(Observatori de Bioètica i Dret, Parc Científic de Barcelona, 2006-10) Gonzàlez-Duarte, Roser
Panorama de la genètica, la recerca i les dones científiques a Espanya

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