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2020-09

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cc by-nc-nd (c) Companys Alemany, Júlia et al., 2020
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/170656

Pharmacological inhibition of soluble epoxide hydrolase protects cognitive impairment in a Niemann-Pick mice model

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Abstract

Niemann-Pick type C (NPC) disease is a childhood autosomal recessive inherited rare neurodegenerative disease characterized by accumulation of cholesterol and glycosphingolipids and where the autophagy-lysosome system and inflammatory processes are implicated in the pathogenesis of the disease. We follow a novel approach to deal with NPC disease, by modulating key features of the disease such as inflammation and autophagy, through inhibition of soluble epoxide hydrolase (sEH).

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Malalties de Niemann-Pick, Trastorns del metabolisme, Cognició

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Niemann-Pick diseases, Disorders of metabolism, Cognition

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Comunicacions a congressos (Farmacologia, Toxicologia i Química Terapèutica)
Comunicacions a congressos (Genètica, Microbiologia i Estadística)
Comunicacions a congressos (Institut de Biomedicina (IBUB))
Comunicacions a congressos (Institut de Neurociències (UBNeuro))

Citation

COMPANYS ALEMANY, Júlia, et al. Pharmacological inhibition of soluble epoxide hydrolase protects cognitive impairment in a Niemann-Pick mice model. Pòster presentat a: 33rd European College of Neuropsychopharmacology (ECNP) Congress. 12-15 September 2020. [consulted: 16 of June of 2026]. Available at: https://hdl.handle.net/2445/170656

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