Comunicacions a congressos (Institut de Neurociències (UBNeuro))

URI permanent per a aquesta col·leccióhttps://hdl.handle.net/2445/119895

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'Marcadores' emocionales de respuestas (des)adaptativas en cáncer
(2024-06-05) Fusté Escolano, Adela; Estapé, T.; Ruiz Rodríguez, José; Estapé, J.
Recovering the intangible acoustic heritage of rock art sites: El Tajo de las Figuras as a case study
(IEEE, 2023-09-05) Alvarez-Morales, Lidia; Santos da Rosa, Neemias; Benítez Aragón, Daniel; Lazarich, María; Díaz-Andreu, Margarita
Since the end of the 19th century, scholars have highlighted the importance of rock art as a priceless heritage that may provide clues about the cultural and spiritual practices of prehistoric societies. However, most studies developed so far have focused only on the materiality of such archaeological remains. In this sense, the ERC Artsoundscapes project –funded by the European Research Council (H2020 programme, Grant Number 787842)– aims at exploring the intangible dimension of rock art sites in relation to auditory experience. Through a multidisciplinary approach comprising archaeological research, ethnomusicology, impulse response measurements, psychoacoustic tests based on auralisations and neuropsicological tests, the project investigates the role of sound and emotion in relation to the sacred by recovering the acoustic heritage of rock art sites in several rock art landscapes of the world. In this paper, we present a case study centred on the El Tajo de las Figuras (Cádiz, Spain), one of the most remarkable rock art sites of the Iberian Peninsula. The results indicate the presence of reverberation, which is especially relevant when considering its small size and, that the site is partially open. This, along with the great strength values obtained, suggests that the shelter morphology could have contributed to creating an acoustic environment suitable for reproducing certain types of music and rhythms that prehistoric people might have used in ceremonies and rituals potentially developed in this decorated space.
Psychoacoustics of rock art sites: the case study of the shelters Diosa I and Horadada (Cádiz, Spain)
(IEEE, 2023-09-05) López-Mochales, Samantha; Alvarez-Morales, Lidia; Santos da Rosa, Neemias; Lazarich, María; Díaz-Andreu, Margarita; Escera i Micó, Carles
The Artsoundscapes project seeks to understand the role of acoustics in the selection by past communities of certain environments to set activities involving rock art production. Within this framework, this article addresses the subjective perception of the acoustics of two rock art sites located in Cádiz (Spain): Diosa I and Horadada. The psychoacoustics of these two rock art sites is investigated by means of two separate listening tests. In the first test, a group of participants develops a corpus of words to subjectively describe the acoustic features of the selected sites. In the second test, a different group of participants rates the descriptors assigned by the first group. The auralizations, rendered via a third order Ambisonics speaker array, consisted of ten sounds of different characteristics (including singing, speech and music) convolved with a set of impulse responses gathered at the selected sites.
Chromatin modifiers MET-2 and SET-25 are required for behavioural and molecular inheritance after early-life toxic stress in C. elegans
(2020-09) Griñán Ferré, Christian; Bellver Sanchis, Aina; Hidalgo-Riubal, Carlos; Gecse, Eszter; Pallàs i Llibería, Mercè, 1964-; Söti, Csaba
Stress exposure early in life is associated with behavioural and bodily changes that can develop several neuropsychiatric illnesses such as dementia. Experiences during the critical perinatal period form permanent, imprinted memories that can persistently alter expression levels of key genes through epigenetic marking, which can underpin changes in behaviour, molecular and stress responsivity throughout later life, including the next generations. Besides, this implies that gene by environment interactions (such as through epigenetic modifications) may be involved in the onset of these phenotypes. Although there are a number of studies in this field, there are still research gaps. For this reason, understanding the molecular mechanisms underlying the enduring effects of early-life stress is an important research area of the neuroscience. The aim of this project is to determine the behavioural and molecular changes and if there are changes in the epigenetic enzymes that can explain in part this phenomenon. Here using an experimental paradigm, we report that in response to early-life stresses, Caenorhabditis elegans nematodes form an imprinted behavioural and cellular defence memory. We show that exposing newly-born worms to toxic antimycin A exposure or repeated exposure, promotes aversive behaviour through chemotaxis assay and stimulates the expression of the hsp-6 enzyme a toxinspecific cytoprotective. Learned adult defences require memory formation during the L1 larval stage and do not appear to confer increased protection against the toxin. We found that aversive behaviour is inherited only to the F1 generation after 1 exposure to the toxic or can be passed to the F4 generation after 4 exposures to the toxic. At the molecular level, we found changes in the chromatin modifiers MET-2 and SET-25 as well as their target gene SKN-1 until the F3 generation after 1 exposure to the toxic or until the F5 generation after 4 exposures to the toxic stress. Furthermore, we found changes in the lifespan after 1 exposure in the F1 until F3 generations as well as in the F1 until F5 generations after 4 exposures to the toxic stimulus. Regarding the oxidative stress response, we found changes in the same generations after 1 exposure or after 4 exposures to early life toxic stress. Thus, exposure of Caenorhabditis elegans to toxic stresses in the critical period elicits adaptive behavioural and cytoprotective responses as we all as promote changes in the health outcomes, demonstrating a wide range of alterations that can appear after an early-life harmful stimulus. Likewise, we can conclude that these results are orchestrated by SET-25 pathway through SKN-1 transcription factor, which forms imprinted aversive behaviour and imprints a cytoprotective memory in the adulthood and the successive generations. These results, open a new avenue for new epigenetic therapies for neuropsychiatric disorders through chromatin
Pharmacological inhibition of soluble epoxide hydrolase protects cognitive impairment in a Niemann-Pick mice model
(2020-09) Companys Alemany, Júlia; Cozar, Mónica; Grinberg Vaisman, Daniel Raúl; Vilageliu i Arqués, Lluïsa; Codony Gisbert, Sandra; Vázquez Cruz, Santiago; Pallàs i Llibería, Mercè, 1964-; Griñán Ferré, Christian
Niemann-Pick type C (NPC) disease is a childhood autosomal recessive inherited rare neurodegenerative disease characterized by accumulation of cholesterol and glycosphingolipids and where the autophagy-lysosome system and inflammatory processes are implicated in the pathogenesis of the disease. We follow a novel approach to deal with NPC disease, by modulating key features of the disease such as inflammation and autophagy, through inhibition of soluble epoxide hydrolase (sEH).
11B-HSD1 inhibition rescues cognitive disturbances after chronic mild stress in mice: target engagement determination through TAPS assay
(2020-06) Puigoriol Illamola, Dolors; Companys Alemany, Júlia; Mole, D. J.; Homer, N.; Vázquez Cruz, Santiago; Griñán Ferré, Christian; Pallàs i Llibería, Mercè, 1964-
With the increase in life expectancy, the study of age-related diseases and the development of different strategies to deal with them become mandatory. Cognitive and behavioural disturbances are growing public healthcare issue for the modern society, which is experiencing an increasingly common stressful lifestyle. Taking into consideration the convergence of aging, stress and neurodegenerative diseases, such as AD, there is impaired glucocorticoid (GC) signalling. Therefore, the study of GC-mediated stress response to chronic moderate stressful (CMS) situations, as account in the daily life, becomes of huge interest in order to design pharmacological strategies to prevent neurodegeneration. Several pieces of evidence link the inhibition of 11β-HSD1 with reduction of GC levels and cognitive improvement, while CMS exposure has been associated with reduced cognitive performance. The aim of this project was to assess whether RL-118 treatment, an 11β-HSD1 inhibitor, could restore the deleterious effects of CMS on cognition and behavioural abilities, but also acts on molecular mechanisms that compromise healthy aging in SAMP8 mice.
L'eix microbiota-cervell i els trastorns de l'ànim
(Universitat de Barcelona. Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), 2017-11-16) Grande i Fullana, Iria

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