Comunicacions a congressos (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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XVII Post-ECTRIMS Meeting: Review of the New Developments Presented at the 2024 ECTRIMS Congress (II)
(IMR Press, 2026-01-21) Fernández, Óscar; Arés, Adrián; Agüera, Eduardo; Aladro, Yolanda; Alonso, Ana; Arroyo, Rafael; Brieva, Luis; Calles, Carmen; Belén Caminero, Ana; Castillo Triviño, Tamara ; Costa Frossard, Lucienne ; Eichau, Sara; Ángel Hernández, Miguel; Landete, Lamberto; Llaneza, Miguel; Llufriu, Sara; Meca Lallana, José E. ; Meca Lallana, Virginia ; Moral, Ester; Oreja Guevara, Celia ; María Prieto, José; Romero Pinel, Lucía María ; Vilaseca, Andreu; Rodríguez Antigüedad, Alfredo
Introduction: The XVII edition of the post-European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) meeting was held on 4-5 October 2024 in Madrid. This event was attended by Spanish neurologists specialized in multiple sclerosis (MS), who presented a summary of the most relevant advances discussed at the ECTRIMS congress, held days before in Copenhagen.Aim: To summarize the main new findings in clinical research on MS.Content and Conclusions: The immunological changes throughout life and in response to MS treatments were analyzed. The impact of aging was also discussed, along with new developments related to symptomatic treatments, physical exercise, fatigue, and sleep disorders. Emphasis was placed on addressing ongoing challenges in measuring therapeutic failure and managing treatments for secondary progressive MS. Additionally, data from registries and real-world studies were presented, including new analyses on cladribine, highlighting the need to collect safety information. Regarding immune reconstitution therapies, mechanisms of action and the immune system's reconstitution process after treatment were explored. Finally, regarding therapeutic innovations, the first results from chimeric antigen receptor (CAR)-T cell therapy studies in MS were reported, representing a promising advancement in disease management.
XVII Post-ECTRIMS Meeting: Review of the New Developments Presented at the 2024 ECTRIMS Congress (I)
(IMR Press, 2026-01-21) Fernández, Óscar; Arés, Adrián; Agüera, Eduardo; Aladro, Yolanda; Alonso, Ana; Arroyo, Rafael; Brieva, Luis; Calles, Carmen; Caminero, Ana Belén; Castillo Triviño, Tamara ; Costa Frossard, Lucienne; Eichau, Sara; Hernández, Miguel Ángel; Landete, Lamberto; Llaneza, Miguel; Llufriu, Sara; Meca Lallana, José E. ; Meca Lallana, Virginia ; Moral, Ester; Oreja Guevara, Celia; María Prieto, José; Romero Pinel, Lucía María ; Vilaseca, Andreu; Rodríguez Antigüedad, Alfredo
Introduction: The XVII edition of the post-European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) meeting was held on 4-5 October 2024 in Madrid. This event was attended by Spanish neurologists specialized in multiple sclerosis (MS), who presented a summary of the most relevant advances discussed at the ECTRIMS congress, held days before in Copenhagen. Aim: To present new developments in neurodegeneration and progression, the prodromal phase and diagnosis, the clinical use of biomarkers and neuroimaging, as well as the current role of patient-reported outcomes and digital monitoring. Highlights on the risk of infections and comorbidities in MS are also summarized. Content and Conclusions: In active MS lesions, there is no correlation between the myeloid cell phenotype and remyelination, while memory astrocytes, regulated by the CLEC16A gene, are present in chronic active lesions. Gray matter atrophy is associated with disability and progression independent of relapses, whereas cervical spinal cord atrophy predicts the prognosis of progressive forms and may lead to earlier diagnosis. Healthcare resource utilization increases in the years preceding the first demyelinating event, and although prodromal symptoms are highly variable, they are useful in identifying risk factors for the disease. The new McDonald criteria will facilitate the diagnosis of MS in patients with a radiologically isolated syndrome. Glial fibrillary acidic protein complements neurofilaments, and both biomarkers could soon be standardized for use in clinical practice; paramagnetic rim lesions and slowly expanding lesions are promising imaging markers. In another area, patient-reported health outcomes are valuable, although they are subject to selection bias and the need to define boundaries for their use. Finally, the risk of infections increases before diagnosis and may worsen with certain treatments. Comorbidities in MS should be managed as an integral part of disease management.
Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1
(Elsevier BV, 2020-05-05) Herkenne, Stéphanie; Ek, Olivier; Zamberlan, Margherita; Pellattiero, Anna; Chergova, Maya; Chivite, Íñigo; Novotná, Eliška; Rigoni, Giovanni; Fonseca, Tiago Branco; Samardzic, Dijana; Agnellini, Andrielly; Bean, Camilla; Di Benedetto, Giulietta; Tiso, Natascia; Argenton, Francesco; Viola, Antonella; Soriano, Maria Eugenia; Giacomello, Marta; Ziviani, Elena; Sales, Gabriele; Claret i Carles, Marc; Graupera i Garcia-Milà, Mariona; Scorrano, Luca
While endothelial cell (EC) function is influenced by mitochondrial metabolism, the role of mitochondrial dynamics in angiogenesis, the formation of new blood vessels from existing vasculature, is unknown. Here we show that the inner mitochondrial membrane mitochondrial fusion protein optic atrophy 1 (OPA1) is required for angiogenesis. In response to angiogenic stimuli, OPA1 levels rapidly increase to limit nuclear factor kappa-light-chain-enhancer of activated B cell (NFκB) signaling, ultimately allowing angiogenic genes expression and angiogenesis. Endothelial Opa1 is indeed required in an NFκB-dependent pathway essential for developmental and tumor angiogenesis, impacting tumor growth and metastatization. A first-in-class small molecule-specific OPA1 inhibitor confirms that EC Opa1 can be pharmacologically targeted to curtail tumor growth. Our data identify Opa1 as a crucial component of physiological and tumor angiogenesis.
Hierarchical Structure of Maladaptive Personality Traits
(2018-09) Ruiz Rodríguez, José; Gutiérrez, Fernando; Peri, Josep M.
Objective: Examine in a clínical samplc the joint hierarchical structurc of personality pathology derived from the 25 primary facets of the Personolity Invenlory (PI D-S; Krueger el al. , 2012) for the fifth edition of Diagnostic and Statistical Man ual of Mental Disorders (DSM-S; sectíon 111) and the 18 traits domains of the Dimensional Assessment of Personality Pathologiy-Basic Quesrionnaire (DAPP-BQ: Livesley & Jackson. 2009).
Lignans and chronic diseases: results from the PREDIMED trial
(Universitat de Barcelona. Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), 2017-11-16) Tresserra i Rimbau, Anna; Estruch Riba, Ramon; Martínez-González, Miguel Ángel, 1957-; Fitó Colomer, Montserrat; Corella Piquer, Dolores; Salas Salvadó, Jordi; Guasch-Ferré, Marta; Rimm, Eric B.; Lamuela Raventós, Rosa Ma.; PREDIMED Study Investigators
Effects of red wine and different doses of polyphenols from dealcoholised red wine on endothelial function in subjects with metabolic syndrome
(Universitat de Barcelona. Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), 2017-11-16) Sasot Flix, Gemma M.; Creus-Cuadros, Anna; Mercader-Martí, M.; Lamuela Raventós, Rosa Ma.; Estruch Riba, Ramon
Different polyphenol excretion between two populations following a 40th parallel diet
(Universitat de Barcelona. Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), 2017-11-16) Marhuenda-Muñoz, María; Lozano-Castellón, Julián; Vilas-Franquesa, Arnau; Ros Rahola, Emilio; Sala Vila, Aleix; Cofán Pujol, Montserrat; Lamuela Raventós, Rosa Ma.
L'eix microbiota-cervell i els trastorns de l'ànim
(Universitat de Barcelona. Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), 2017-11-16) Grande i Fullana, Iria
Microbial metabolites are associated with a high adherence to a Mediterranean dietary pattern using a 1H-NMR-based untargeted metabolomics approach [Congrés]
(Universitat de Barcelona. Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), 2017-11-16) Almanza Aguilera, Enrique; Urpí Sardà, Mireia; Llorach, Rafael; Vázquez Fresno, Rosa; Garcia Aloy, Mar; Carmona Pontaque, Francesc; Sànchez, Àlex (Sànchez Pla); Madrid Gambín, Francisco Javier; Estruch Riba, Ramon; Corella Piquer, Dolores; Andrés Lacueva, Ma. Cristina

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