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URI permanent per a aquesta col·leccióhttps://hdl.handle.net/2445/119042

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Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1
(Elsevier BV, 2020-05-05) Herkenne, Stéphanie; Ek, Olivier; Zamberlan, Margherita; Pellattiero, Anna; Chergova, Maya; Chivite, Íñigo; Novotná, Eliška; Rigoni, Giovanni; Fonseca, Tiago Branco; Samardzic, Dijana; Agnellini, Andrielly; Bean, Camilla; Di Benedetto, Giulietta; Tiso, Natascia; Argenton, Francesco; Viola, Antonella; Soriano, Maria Eugenia; Giacomello, Marta; Ziviani, Elena; Sales, Gabriele; Claret i Carles, Marc; Graupera i Garcia-Milà, Mariona; Scorrano, Luca
While endothelial cell (EC) function is influenced by mitochondrial metabolism, the role of mitochondrial dynamics in angiogenesis, the formation of new blood vessels from existing vasculature, is unknown. Here we show that the inner mitochondrial membrane mitochondrial fusion protein optic atrophy 1 (OPA1) is required for angiogenesis. In response to angiogenic stimuli, OPA1 levels rapidly increase to limit nuclear factor kappa-light-chain-enhancer of activated B cell (NFκB) signaling, ultimately allowing angiogenic genes expression and angiogenesis. Endothelial Opa1 is indeed required in an NFκB-dependent pathway essential for developmental and tumor angiogenesis, impacting tumor growth and metastatization. A first-in-class small molecule-specific OPA1 inhibitor confirms that EC Opa1 can be pharmacologically targeted to curtail tumor growth. Our data identify Opa1 as a crucial component of physiological and tumor angiogenesis.
Hierarchical Structure of Maladaptive Personality Traits
(2018-09) Ruiz Rodríguez, José; Gutiérrez, Fernando; Peri, Josep M.
Objective: Examine in a clínical samplc the joint hierarchical structurc of personality pathology derived from the 25 primary facets of the Personolity Invenlory (PI D-S; Krueger el al. , 2012) for the fifth edition of Diagnostic and Statistical Man ual of Mental Disorders (DSM-S; sectíon 111) and the 18 traits domains of the Dimensional Assessment of Personality Pathologiy-Basic Quesrionnaire (DAPP-BQ: Livesley & Jackson. 2009).
Lignans and chronic diseases: results from the PREDIMED trial
(Universitat de Barcelona. Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), 2017-11-16) Tresserra i Rimbau, Anna; Estruch Riba, Ramon; Martínez-González, Miguel Ángel, 1957-; Fitó Colomer, Montserrat; Corella Piquer, Dolores; Salas Salvadó, Jordi; Guasch-Ferré, Marta; Rimm, Eric B.; Lamuela Raventós, Rosa Ma.; PREDIMED Study Investigators
Effects of red wine and different doses of polyphenols from dealcoholised red wine on endothelial function in subjects with metabolic syndrome
(Universitat de Barcelona. Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), 2017-11-16) Sasot Flix, Gemma M.; Creus-Cuadros, Anna; Mercader-Martí, M.; Lamuela Raventós, Rosa Ma.; Estruch Riba, Ramon
Different polyphenol excretion between two populations following a 40th parallel diet
(Universitat de Barcelona. Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), 2017-11-16) Marhuenda-Muñoz, María; Lozano-Castellón, Julián; Vilas-Franquesa, Arnau; Ros Rahola, Emilio; Sala Vila, Aleix; Cofán Pujol, Montserrat; Lamuela Raventós, Rosa Ma.
L'eix microbiota-cervell i els trastorns de l'ànim
(Universitat de Barcelona. Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), 2017-11-16) Grande i Fullana, Iria
Microbial metabolites are associated with a high adherence to a Mediterranean dietary pattern using a 1H-NMR-based untargeted metabolomics approach [Congrés]
(Universitat de Barcelona. Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), 2017-11-16) Almanza Aguilera, Enrique; Urpí Sardà, Mireia; Llorach, Rafael; Vázquez Fresno, Rosa; Garcia Aloy, Mar; Carmona Pontaque, Francesc; Sànchez, Àlex (Sànchez Pla); Madrid Gambín, Francisco Javier; Estruch Riba, Ramon; Corella Piquer, Dolores; Andrés Lacueva, Ma. Cristina

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