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Title: Perspective: Metabotyping-A Potential Personalized Nutrition Strategy for Precision Prevention of Cardiometabolic Disease
Author: Palmnäs, Marie
Brunius, Carl
Shi, Lin
Rostgaard-Hansen, Agneta
Estanyol Torres, Núria
González-Domínguez, Raúl
Zamora-Ros, Raul
Ye Lingqun, Ye
Halkjær, Jytte
Tjønneland, Anne
Riccardi, Gabriele
Giacco, Rosalba
Costabile, Giuseppina
Vetrani, Claudia
Nielsen, Jens
Andrés Lacueva, Ma. Cristina
Landberg, Rikard
Keywords: Metabolòmica
Issue Date: 2019
Publisher: American Society for Nutrition
Abstract: Diet is an important, modifiable lifestyle factor of cardiometabolic disease risk, and an improved diet can delay or even prevent the onset of disease. Recent evidence suggests that individuals could benefit from diets adapted to their genotype and phenotype: that is, personalized nutrition. A novel strategy is to tailor diets for groups of individuals according to their metabolic phenotypes (metabotypes). Randomized controlled trials evaluating metabotype-specific responses and nonresponses are urgently needed to bridge the current gap of knowledge with regard to the efficacy of personalized strategies in nutrition. In this Perspective, we discuss the concept of metabotyping, review the current literature on metabotyping in the context of cardiometabolic disease prevention, and suggest potential strategies for metabotype-based nutritional advice for future work. We also discuss potential determinants of metabotypes, including gut microbiota, and highlight the use of metabolomics to define effective markers for cardiometabolic disease-related metabotypes. Moreover, we hypothesize that people at high risk for cardiometabolic diseases have distinct metabotypes and that individuals grouped into specific metabotypes may respond differently to the same diet, which is being tested in a project of the Joint Programming Initiative: A Healthy Diet for a Healthy Life.
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It is part of: Advances in Nutrition, 2019, vol. 11, num. 3, p. 524-532
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ISSN: 2161-8313
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)

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