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Title: Mediterranean diet and white blood cell count - A randomized controlled trial.
Author: Hernáez Camba, Álvaro
Lassale, Camille
Castro Barquero, Sara
Babio, Nancy
Ros Rahola, Emilio
Castañer, Olga
Tresserra i Rimbau, Anna
Pintó Sala, Xavier
Martínez-González, Miguel Ángel, 1957-
Corella Piquer, Dolores
Salas Salvadó, Jordi
Alonso Gómez, Ángel M.
Lapetra, José
Fiol Sala, Miguel
Gómez Gracia, Enrique
Serra Majem, Lluís
Sacanella Meseguer, Emilio
Garcia-Arellano, Ana
Sorlí, José V.
Díaz López, Andrés
Cofán Pujol, Montserrat
Estruch Riba, Ramon
Keywords: Leucòcits
Cuina mediterrània
Malalties hematològiques
Mediterranean cooking
Hematologic diseases
Issue Date: 2-Jun-2021
Publisher: MDPI
Abstract: We aimed to assess the effects of the antioxidant-rich Mediterranean diet (MedDiet) onwhite blood cell count. Our study population included participants in the PREvención con DIetaMEDiterránea study (average age 67 years old, 58% women, high cardiovascular risk). We assessedwhether a MedDiet intervention enriched in extra-virgin olive oil or nuts, versus a low-fat controldiet, modified the incidence of leukocytosis (>11×109leukocytes/L), mild leukopenia (<4.5×109leukocytes/L), or severe leukopenia (<3.5×109leukocytes/L) in individuals without the conditionat baseline (n= 3190,n= 2925, andn= 3190, respectively). We also examined whether MedDietmodified the association between leukocyte count alterations and all-cause mortality. Both MedDietinterventions were associated with a lower risk of developing leukopenia (incidence rates: 5.06%in control diet, 3.29% in MedDiet groups combined; hazard ratio [95% confidence interval]: 0.54[0.36-0.80]) and severe leukopenia (incidence rates: 1.26% in control diet, 0.46% in MedDiet groupscombined; hazard ratio: 0.25 [0.10-0.60]). High cumulative adherence to a MedDiet was linked tolower risk of leukocytosis (incidence rates: 2.08% in quartile 1, 0.65% in quartile 4; HRQ4-Q1: 0.29[0.085-0.99]) and attenuated the association between leukopenia and all-cause mortality (P-interaction= 0.032). In brief, MedDiet decreased the incidence of white blood cell count-related alterations inhigh cardiovascular risk individuals.
Note: Reproducció del document publicat a:
It is part of: Foods, 2021, vol. 10, num. 6, p. 1268
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ISSN: 2304-8158
Appears in Collections:Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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