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Title: | The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease |
Author: | Urpí Sardà, Mireia Casas Rodríguez, Rosa M. Sacanella Meseguer, Emilio Corella Piquer, Dolores Andrés Lacueva, Ma. Cristina Llorach, Rafael Garrabou Tornos, Glòria Cardellach, Francesc Sala Vila, Aleix Ros Rahola, Emilio Ruiz-Canela, Miguel Fitó Colomer, Montserrat Salas Salvadó, Jordi Estruch Riba, Ramon |
Keywords: | Malalties cardiovasculars Expressió gènica Inflamació Nutrició Cardiovascular diseases Gene expression Inflammation Nutrition |
Issue Date: | 22-Jul-2021 |
Publisher: | MDPI |
Abstract: | The intervention with the Mediterranean diet (MD) pattern has evidenced short-term anti-inflammatory effects, but little is known about its long-term anti-inflammatory properties at molecular level. This study aims to investigate the 3-year effect of MD interventions compared to low-fat diet (LFD) on changes on inflammatory biomarkers related to atherosclerosis in a free-living population with a high-risk of cardiovascular disease (CD). Participants (n = 285) in the PREDIMED trial were randomly assigned into three intervention groups: MD with extra-virgin olive oil (EVOO) or MD-Nuts, and a LFD. Fourteen plasma inflammatory biomarkers were determined by Luminex assays. An additional pilot study of gene expression (GE) was determined by RT-PCR in 35 participants. After 3 years, both MDs showed a significant reduction in the plasma levels of IL-1β, IL-6, IL-8, TNF-α, IFN-γ, hs-CRP, MCP-1, MIP-1β, RANTES, and ENA78 (p < 0.05; all). The decreased levels of IL-1β, IL-6, IL-8, and TNF-α after MD significantly differed from those in the LFD (p < 0.05). No significant changes were observed at the gene level after MD interventions, however, the GE of CXCR2 and CXCR3 tended to increase in the control LFD group (p = 0.09). This study supports the implementation of MD as a healthy long-term dietary pattern in the prevention of CD in populations at high cardiovascular risk. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/biomedicines9080862 |
It is part of: | Biomedicines, 2021 |
URI: | http://hdl.handle.net/2445/181332 |
Related resource: | https://doi.org/10.3390/biomedicines9080862 |
ISSN: | 2227-9059 |
Appears in Collections: | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) Articles publicats en revistes (Medicina) |
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