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2025-07-01

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cc-by (c) Society of Biological Psychiatry, 2024
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/223676

Atlas of Gray Matter Volume Differences Across Psychiatric Conditions: A Systematic Review With a Novel Meta-Analysis That Considers Co-Occurring Disorders

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https://doi.org/10.1016/j.biopsych.2024.10.020

Resum

Background Regional gray matter volume (GMV) differences between individuals with mental disorders and comparison participants may be confounded by co-occurring disorders. To disentangle disorder-specific GMV correlates, we conducted a large-scale multidisorder meta-analysis using a novel approach that explicitly models co-occurring disorders. Methods We systematically reviewed voxel-based morphometry studies indexed in PubMed and Scopus up to January 2023 that compared adults with major mental disorders (anorexia nervosa, schizophrenia spectrum, anxiety, bipolar, major depressive, obsessive-compulsive, and posttraumatic stress disorders plus attention-deficit/hyperactivity, autism spectrum, and borderline personality disorders) with comparison participants. Two authors independently extracted data and assessed quality using the Newcastle-Ottawa Scale. We derived GMV correlates for each disorder using: 1) a multidisorder meta-analysis that accounted for all co-occurring mental disorders simultaneously and 2) separate standard meta-analyses for each disorder in which co-occurring disorders were ignored. We assessed the alterations’ extent, intensity (effect size), and specificity (interdisorder correlations and transdiagnostic alterations) for both approaches. Results We included 433 studies (499 datasets) involving 19,718 patients and 16,441 comparison participants (51% female, ages 20–67 years). We provide GMV correlate maps for each disorder using both approaches. The novel approach, which accounted for co-occurring disorders, produced GMV correlates that were more focal and disorder specific (less correlated across disorders and fewer transdiagnostic abnormalities).

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Neuropsiquiatria, Mapatge del cervell, Psiquiatria biològica

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Neuropsychiatry, Brain mapping, Biological psychiatry

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Psicologia Social i Psicologia Quantitativa)

Citació

FORTEA, Lydia, ORTUÑO, María, DE PRISCO, Michele, OLIVA, Vincenzo, ALBAJES EIZAGIRRE, Anton, FORTEA, Adriana, MADERO GÓMEZ, Santiago, SOLANES, Aleix, VILAJOSANA, Enric, YAO, Yuanwei, FABRO, Lorenzo del, SOLÉ, Eduard, VERDOLINI, Norma, FARRÉ COLOMÉS, Álvar, SERRA BLASCO, María, PICÓ PÉREZ, Maria, LUKITO, Steve, WISE, Toby, CARLISI, Christina, ARNONE, Danilo, KEMPTON, Matthew j., HAUSON, Alexander o., WOLLMAN, Scott c., SORIANO MAS, Carles, RUBIA, Katya, NORMAN, Luke, FUSAR-POLI, Paolo, MATAIX-COLS, David, VALENTÍ RIBAS, Marc, VIA VIRGILI, Esther, CARDONER, N. (narcís), SOLMI, Marco, ZHANG, Jintao, PAN, Pinglei, SHIN, Jae i., FULLANA RIVAS, Miguel àngel, VIETA I PASCUAL, Eduard, RADUA, Joaquim. Atlas of Gray Matter Volume Differences Across Psychiatric Conditions: A Systematic Review With a Novel Meta-Analysis That Considers Co-Occurring Disorders. _Biological Psychiatry_. 2025. Vol. 98, núm. 1, pàgs. 76-90. [consulta: 10 de desembre de 2025]. ISSN: 0006-3223. [Disponible a: https://hdl.handle.net/2445/223676]

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