Llibres / Capítols de llibre (Institut de Recerca en Nutrició i Seguretat Alimentària (INSA·UB))

URI permanent per a aquesta col·leccióhttps://diposit.ub.edu/handle/2445/96582

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Mostrant 1 - 4 de 4
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    Immunomodulatory role of probiotics in early life
    (Research Signpost, 2017) Rodríguez Lagunas, María José; Azagra Boronat, Ignasi; Saldaña-Ruíz, Sandra; Massot Cladera, Malen; Rigo Adrover, Maria del Mar; Sabaté-Jofre, Anna; Franch i Masferrer, Àngels; Castell, Margarida; Pérez-Cano, Francisco J.
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    Bioavailability and metabolism of maslinic acid, a natural pentacyclic triterpene
    (Research Signpost, 2016) Juan i Olivé, M. Emília; Planas i Rosselló, Joana M.
    Maslinic acid is a pentacyclic triterpene found in plants used in traditional medicine with antidiabetic, antitumor, antioxidant and parasitostatic activities. A diet rich in foods of plant origin could provide a regular supply of this bioactive compound since it has been detected in olives, spinaches, eggplants, chickpeas and pomegranates. The multiple biological effects elicited by maslinic acid suggest its putative use as nutraceutical. This review summarizes our study on the safety, pharmacokinetics, and metabolism after the oral administration of maslinic acid, conducted with the aim of increasing the knowledge about the bioavailability of this bioactive food component.
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    Risk assessment for human embryonic development of triclabendazole residues in milk and cheese in the diet of a rural population in Cajamarca (Peru): A preliminary approach
    (Research Signpost, 2016) Boix Sabrià, Núria; Teixidó Condomines, Elisabet; Vila Cejudo, Marta; Ortiz, Pedro; Ibáñez, Elena; Gómez Catalán, Jesús; Llobet Mallafré, Joan M. (Joan Maria); Barenys Espadaler, Marta
    Triclabendazole (TCBZ) is a veterinary drug used against Fasciola hepatica in cattle. The Cajamarca Valley in Peru is an endemic area of fascioliasis with a high infection rate in animals producing milk for human consumption. The administration of TCBZ during the lactating period can lead to TCBZ derivative residues in milk and cheese entering the human food chain. Milk-derivatives from treated animals have been found positive for TCBZ metabolites. One of these metabolites, triclabendazole sulfoxide (TCBZSO), is embryolethal during early developmental stages in vitro in mouse and zebrafish. In this study, we have calculated the estimated daily intake (EDI) of TCBZSO due to milk and cheese consumption among a rural population in Cajamarca in order to evaluate the associated risk for human embryonic development. Although the expected maximum plasma concentration of TCBZSO after a worst-case scenario simulation would be below the reported lowest observed adverse effect concentration (LOAEC) for embryolethality in vitro (10 μM), several limitations on the available information for exposure, bioavailability and interspecies differences still impede the accomplishment of an accurate risk assessment.
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    Dietary spray-dried animal plasma alleviates mucosal inflammation in experimental models
    (Research Signpost, 2015) Pérez Bosque, Anna; Moretó, Miquel, 1950-
    The intestinal and bronchoalveolar mucosae contribute to homeostasis by preventing the entrance of biological and chemical agents that could alter the stability of the system. In this review, we summarise the main effects of dietary supplementation with spray-dried plasma (SDP), a complex mixture of biologically active functional components, on two models of acute inflammation; a murine model of intestinal inflammation, based on the administration of S. aureus enterotoxin B (SEB), and a model of acute lung inflammation, using mice challenged with lipopolysaccharide from E. coli (LPS). Oral SDP modulates the immune response of the intestinal mucosa and restores the barrier function of the epithelium, preventing most of the effects of SEB on defensin expression, tight-junction permeability and mucosal cytokine production. In the lung, SDP supplementation partially prevents the LPS-induced release of pro-inflammatory cytokines, an effect that involves the participation of the common mucosal immune system. In both models, the effects of SDP are mediated by an increased T-reg response and enhanced release of anti-inflammatory cytokines that contribute to mucosal homeostasis.