Carregant...
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/220497
Biomarkers of Oxidation, Inflammation and Intestinal Permeability in Persons with Diabetes Mellitus with Parenteral Nutrition: a Multicenter Randomized Trial
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Background and aims: Parenteral nutrition (PN) composition could play a role in the management of systemic inflammatory response and intestinal barrier disruption. We aimed to evaluate changes in biomarkers of inflammation, oxidative status and intestinal permeability in patients with type 2 diabetes mellitus (T2DM) who received different PN lipid formulas. Methods: This was a prospective study, including 94 patients with T2DM who received omega (n)-3 polyunsaturated fatty acids (PUFA)-enriched PN, a mixture of medium and long chain triglycerides (MCT/ LCT) PN, or an olive oil-based PN. Serum levels of biomarkers of oxidative status, intestinal permeability and inflammation biomarkers were determined at day 1 and day 5 after PN initiation. Registered under ClinicalTrials.gov Identifier no. NCT02706119. Results: At day 5 after the onset of PN, the MCT/LCT group had a significant reduction of 2 proinflammatory cytokines [interleukin (IL)-15, IL-17A], elevation of the anti-inflammatory cytokine IL-13 and increase of zonulin and indoxylsulfate. The olive oil group showed a statistically significant reduction of 5 proinflammatory cytokines [IL-1D, IL-17A, IL-6, cytokine-leukemia inhibitory factor (LIF) and tumor necrosis factor alpha (TNF-a)] and reduced concentrations of the anti-inflammatory cytokine IL-1RA, while the n-3 PUFA-enriched group presented a statistically significant reduction of 8 proinflammatory cytokines (interferon-gamma, IL-1D, IL-15, IL-17A, IL-6, LIF, monocyte chemoattractant protein 1, and TNF-a). In the between-group comparisons, indoxylsulfate significantly increased in the MCT/LCT group compared to the n-3 PUFA-enriched group, while 8-isoprostane and indoxylsulfate significantly increased in the MCT/LCT group compared to the other groups and superoxide dismutase significantly decreased in the MCT/LCT group compared to the other groups. Conclusion: In patients with T2DM, PN lipid composition exerts a profound impact on proinflammatory, prooxidative and intestinal permeability biomarkers.
Matèries (anglès)
Citació
Citació
SORIA UTRILLA, Virginia, SASSO, Corina verónica, ROMERO ZERBO, Silvana yanina, ADARVE CASTRO, Antonio, LÓPEZ URDIALES, Rafael, HERRANZ ANTOLÍN, Sandra, GARCÍA ALMEIDA, José manuel, GARCÍA MALPARTIDA, Katherine, FERRER GÓMEZ, Mercedes, MORENO BORREGUERO, Alicia, LUENGO PÉREZ, Luis miguel, ÁLVAREZ HERNÁNDEZ, Julia, ARAGÓN VALERA, Carmen, OCÓN BRETÓN, María julia, GARCÍA MANZANARES, Álvaro, BRETÓN LESMES, Irene, SERRANO AGUAYO, Pilar, PÉREZ FERRE, Natalia, LÓPEZ GÓMEZ, Juan josé, OLIVARES ALCOLEA, Josefina, MORENO MARTÍNEZ, Macarena, TEJERA PÉREZ, Cristina, GARCÍA ARIAS, Sara, ABAD GONZÁLEZ, Ángel luis, ALHAMBRA EXPÓSITO, María rosa, ZUGASTI MURILLO, Ana, PARRA BARONA, Juan, TORREJÓN JARAMILLO, Sara, ABUIN, José, FERNÁNDEZ GARCÍA, José carlos, OLVEIRA, Gabriel, the Nutrition Area of the Spanish Society of Endocrinology and Nutrition (SEEN). Biomarkers of Oxidation, Inflammation and Intestinal Permeability in Persons with Diabetes Mellitus with Parenteral Nutrition: a Multicenter Randomized Trial. _Clinical Nutrition_. 2025. Vol. 44, núm. 155-164. [consulta: 25 de gener de 2026]. ISSN: 0261-5614. [Disponible a: https://hdl.handle.net/2445/220497]