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2022_IJMS_Differences_DelRio.pdf (3.03 MB)

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2022-04-27

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cc by (c) Ferrer, Isidro (Ferrer Abizanda) et al., 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/185349

Differences in Tau Seeding in Newborn and Adult Wild-Type Mice

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https://doi.org/10.3390/ijms23094789

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Alzheimer’s disease (AD) and other tauopathies are common neurodegenerative diseases in older adults; in contrast, abnormal tau deposition in neurons and glial cells occurs only exceptionally in children. Sarkosyl-insoluble fractions from sporadic AD (sAD) containing paired helical filaments (PHFs) were inoculated unilaterally into the thalamus in newborn and three-month-old wild-type C57BL/6 mice, which were killed at different intervals from 24 h to six months after inoculation. Tau-positive cells were scanty and practically disappeared at three months in mice inoculated at the age of a newborn. In contrast, large numbers of tau-positive cells, including neurons and oligodendrocytes, were found in the thalamus of mice inoculated at three months and killed at the ages of six months and nine months. Mice inoculated at the age of newborn and re-inoculated at the age of three months showed similar numbers and distribution of positive cells in the thalamus at six months and nine months. This study shows that (a) differences in tau seeding between newborn and young adults may be related to the ratios between 3Rtau and 4Rtau, and the shift to 4Rtau predominance in adults, together with the immaturity of connections in newborn mice, and (b) intracerebral inoculation of sAD PHFs in newborn mice does not protect from tau seeding following intracerebral inoculation of sAD PHFs in young/adult mice.

Matèries

Malaltia d'Alzheimer, Tàlem (Anatomia)

Matèries (anglès)

Alzheimer's disease, Thalamus

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Col·leccions

Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

Citació

FERRER, Isidro (ferrer abizanda), ANDRÉS BENITO, Pol, GARCIA ESPARCIA, Paula, LÓPEZ GONZÁLEZ, Irene, VALIENTE, Diego, JORDÁN PIRLA, Mónica, CARMONA MURILLO, Margarita, SALA JARQUE, Julia, GIL FERNÁNDEZ, Vanessa, RÍO FERNÁNDEZ, José antonio del. Differences in Tau Seeding in Newborn and Adult Wild-Type Mice. _International Journal Of Molecular Sciences_. 2022. Vol. 23, núm. 9, pàgs. 4789. [consulta: 2 de febrer de 2026]. ISSN: 1422-0067. [Disponible a: https://hdl.handle.net/2445/185349]

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