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NTC_PhD_THESIS.pdf (87.67 MB)

Document type

Doctoral thesis

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Published version

Publication date

2024-09-20

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cc by-nc-sa (c) Tirado Cabrera, Néstor, 2024
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/216990

New immunotherapeutic strategies in acute leukemia

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Abstract

[eng] AIMS: The general aim of this doctoral thesis is to improve current CAR-T immunotherapeutic strategies in the treatment of acute leukemias. The specific aims of this doctoral thesis are: 1. To develop and characterize CD123-directed CAR-DOT cells as an allogeneic-safe, off-the-shelf therapy far the treatment of R/R AML. 2. To engineer CD1axCD3 BiTE-secreting STAb-T cells and compare their effectiveness against conventional CD1a-directed CAR-T cells against coT-ALL. 3. To generate a CCR9-directed immunotherapy far the safe treatment of R/R T-ALL. (i) To validate CCR9 as an immunotherapeutic target far T-ALL. (ii) To generate CCR9-directed CAR-T cells. (iii) To generate dual CCR9/CD1 a-directed CAR.

Subject

Immunologia, Immunoteràpia, Hematologia, Leucèmia aguda

Subject (English)

Immunology, Immunotheraphy, Hematology, Acute leukemia

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Tesis Doctorals - Facultat - Medicina i Ciències de la Salut

Citation

TIRADO CABRERA, Néstor. New immunotherapeutic strategies in acute leukemia. [consulted: 8 of June of 2026]. Available at: https://hdl.handle.net/2445/216990

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