New immunotherapeutic strategies in acute leukemia

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dc.contributor.advisorMenéndez Buján, Pablo
dc.contributor.advisorSánchez Martínez, Diego
dc.contributor.authorTirado Cabrera, Néstor
dc.contributor.otherUniversitat de Barcelona. Facultat de Medicina i Ciències de la Salut
dc.date.accessioned2024-12-10T10:05:38Z
dc.date.available2024-12-10T10:05:38Z
dc.date.issued2024-09-20
dc.description.abstract[eng] AIMS: The general aim of this doctoral thesis is to improve current CAR-T immunotherapeutic strategies in the treatment of acute leukemias. The specific aims of this doctoral thesis are: 1. To develop and characterize CD123-directed CAR-DOT cells as an allogeneic-safe, off-the-shelf therapy far the treatment of R/R AML. 2. To engineer CD1axCD3 BiTE-secreting STAb-T cells and compare their effectiveness against conventional CD1a-directed CAR-T cells against coT-ALL. 3. To generate a CCR9-directed immunotherapy far the safe treatment of R/R T-ALL. (i) To validate CCR9 as an immunotherapeutic target far T-ALL. (ii) To generate CCR9-directed CAR-T cells. (iii) To generate dual CCR9/CD1 a-directed CAR.ca
dc.format.extent176 p.
dc.format.mimetypeapplication/pdf
dc.identifier.tdxhttp://hdl.handle.net/10803/692700
dc.identifier.urihttps://hdl.handle.net/2445/216990
dc.language.isoengca
dc.publisherUniversitat de Barcelona
dc.rightscc by-nc-sa (c) Tirado Cabrera, Néstor, 2024
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/es/*
dc.sourceTesis Doctorals - Facultat - Medicina i Ciències de la Salut
dc.subject.classificationImmunologia
dc.subject.classificationImmunoteràpia
dc.subject.classificationHematologia
dc.subject.classificationLeucèmia aguda
dc.subject.otherImmunology
dc.subject.otherImmunotheraphy
dc.subject.otherHematology
dc.subject.otherAcute leukemia
dc.titleNew immunotherapeutic strategies in acute leukemiaca
dc.typeinfo:eu-repo/semantics/doctoralThesisca
dc.typeinfo:eu-repo/semantics/publishedVersion

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Tesis Doctorals - Facultat - Medicina i Ciències de la Salut