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Article

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Published version

Publication date

2010

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cc-by (c) Rodríguez García, M. et al., 2010
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/42863

Increased alpha-defensins 1-3 production by dendritic cells in HIV-infected individuals is associated with slower disease progression.

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http://dx.doi.org/10.1371/journal.pone.0009436

Abstract

Defensins are natural endogenous antimicrobial peptides with potent anti-HIV activity and immuno-modulatory effects. We recently demonstrated that immature dendritic cells (DC) produce α-defensins1-3 and that α-defensins1-3 modulate DC generation and maturation. Since DC-HIV interaction plays a critical role during the first steps of HIV infection, we investigated the possible impact of α-defensins1-3 production by DC on disease progression.

Subject

VIH (Virus), Immunologia

Subject (English)

HIV (Viruses), Immunology

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Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
Articles publicats en revistes (Medicina)

Citation

RODRÍGUEZ GARCÍA, Marta, et al. Increased alpha-defensins 1-3 production by dendritic cells in HIV-infected individuals is associated with slower disease progression. PLoS One. 2010. Vol. 5, num. 2, pags. e9436-e9436. ISSN 1932-6203. [consulted: 8 of June of 2026]. Available at: https://hdl.handle.net/2445/42863

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