Increased alpha-defensins 1-3 production by dendritic cells in HIV-infected individuals is associated with slower disease progression.

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dc.contributor.authorRodríguez García, Marta
dc.contributor.authorCliment Vidal, Núria
dc.contributor.authorOliva, Harold
dc.contributor.authorCasanova Güell, Víctor
dc.contributor.authorFranco Fernández, Rafael
dc.contributor.authorLeón García, Agathe
dc.contributor.authorGatell, José M.
dc.contributor.authorGarcía, Felipe
dc.contributor.authorGallart, Teresa
dc.date.accessioned2013-05-07T09:35:44Z
dc.date.available2013-05-07T09:35:44Z
dc.date.issued2010
dc.date.updated2013-05-07T09:35:44Z
dc.description.abstractDefensins are natural endogenous antimicrobial peptides with potent anti-HIV activity and immuno-modulatory effects. We recently demonstrated that immature dendritic cells (DC) produce α-defensins1-3 and that α-defensins1-3 modulate DC generation and maturation. Since DC-HIV interaction plays a critical role during the first steps of HIV infection, we investigated the possible impact of α-defensins1-3 production by DC on disease progression.
dc.format.extent10 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec593531
dc.identifier.issn1932-6203
dc.identifier.pmid20195543
dc.identifier.urihttps://hdl.handle.net/2445/42863
dc.language.isoeng
dc.publisherPublic Library of Science (PLoS)
dc.relation.isformatofReproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0009436
dc.relation.ispartofPLoS One, 2010, vol. 5, num. 2, p. e9436-e9436
dc.relation.urihttp://dx.doi.org/10.1371/journal.pone.0009436
dc.rightscc-by (c) Rodríguez García, M. et al., 2010
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.sourceArticles publicats en revistes (Bioquímica i Biomedicina Molecular)
dc.subject.classificationVIH (Virus)
dc.subject.classificationImmunologia
dc.subject.otherHIV (Viruses)
dc.subject.otherImmunology
dc.titleIncreased alpha-defensins 1-3 production by dendritic cells in HIV-infected individuals is associated with slower disease progression.eng
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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