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Phytosterolemia associated with parenteral nutrition administration in adult patients
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Vegetable lipid emulsions (LE) contain non-declared phytosterols (PS). We aimed to determine PS content depending on the brand and LE batch; and in adult hospitalized patients treated with parenteral nutrition (PN), to establish the association between plasma and administered PS. I. LE study: Totals and fractions of PS in 3-4 non-consecutive batches from 6 LE were analysed. II. Patient study: randomized, double-blind study of patients with at least 7 previous days of PN with 0.8 g/kg/day of an olive/soybean LE, were randomized (Day 0) 1:1 to olive/soybean (O/S) or 100% fish oil (FO) at a dose of 0.4 g/kg/day for 7 days (Day 7). Plasma PS, its fractions, total cholesterol on Days 0 and 7, their clearance, and their association with PS administered by LE were studied. In part I. LE study: differences were found in the total PS, their fractions and cholesterol among different LE brands and batches. Exclusive soybean LE had the highest content of PS (422.36 ± 130.46 μg/mL). II. Patient study: 19 patients were included. In the O/S group, PS levels were maintained (1.11±6.98 μg/mL) from Day 0 to 7, while in the FO group, significant decreases were seen in total PS (-6.21±4.73 μg/mL) and their fractions, except for campesterol and stigmasterol. Plasma PS on Day 7 were significantly associated with PS administered (R2=0.443). PS content in different LE brands had great variability. PS administered during PN resulted in accumulation and could be prevented with the exclusive administration of FO LE.
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LLOP TALAVERÓN, Josep manuel, LEIVA BADOSA, Elisabet, NOVAK, Ana, RIGO BONNIN, Raúl, TICÓ GRAU, Josep r., SUÑÉ I NEGRE, Josep m. (josep maria), SUÁREZ LLEDÓ, Ana, LOZANO ANDREU, Toni, BADÍA TAHULL, Maria. Phytosterolemia associated with parenteral nutrition administration in adult patients. _British Journal of Nutrition_. 2020. Vol. 123, núm. 12, pàgs. 1365-1372. [consulta: 20 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/158715]