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cc-by (c)  Bertran-Mostazo, A. et al., 2024
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/215920

Proximity-induced pharmacology for amyloid-related diseases<br />

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Abstract

Proximity-induced pharmacology (PIP) for amyloid-related diseases is a cutting-edge

approach to treating conditions such as Alzheimer’s disease and other forms of dementia. By bringing

small molecules close to amyloid-related proteins, these molecules can induce a plethora of effects

that can break down pathogenic proteins and reduce the buildup of plaques. One of the most

promising aspects of this drug discovery modality is that it can be used to target specific types of

amyloid proteins, such as the beta-amyloid protein that is commonly associated with Alzheimer’s

disease. This level of specificity could allow for more targeted and effective treatments. With ongoing

research and development, it is hoped that these treatments can be refined and optimized to provide

even greater benefits to patients. As our understanding of the underlying mechanisms of these

diseases continues to grow, proximity-induced pharmacology treatments may become an increasingly

important tool in the fight against dementia and other related conditions.

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BERTRAN-MOSTAZO, Andrea, et al. Proximity-induced pharmacology for amyloid-related diseases
. Cells. 2024. Vol. 13. ISSN 2073-4409. [consulted: 15 of June of 2026]. Available at: https://hdl.handle.net/2445/215920

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