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Proximity-induced pharmacology for amyloid-related diseases<br />
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Abstract
Proximity-induced pharmacology (PIP) for amyloid-related diseases is a cutting-edge
approach to treating conditions such as Alzheimer’s disease and other forms of dementia. By bringing
small molecules close to amyloid-related proteins, these molecules can induce a plethora of effects
that can break down pathogenic proteins and reduce the buildup of plaques. One of the most
promising aspects of this drug discovery modality is that it can be used to target specific types of
amyloid proteins, such as the beta-amyloid protein that is commonly associated with Alzheimer’s
disease. This level of specificity could allow for more targeted and effective treatments. With ongoing
research and development, it is hoped that these treatments can be refined and optimized to provide
even greater benefits to patients. As our understanding of the underlying mechanisms of these
diseases continues to grow, proximity-induced pharmacology treatments may become an increasingly
important tool in the fight against dementia and other related conditions.
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BERTRAN-MOSTAZO, Andrea, et al. Proximity-induced pharmacology for amyloid-related diseases
. Cells. 2024. Vol. 13. ISSN 2073-4409. [consulted: 15 of June of 2026]. Available at: https://hdl.handle.net/2445/215920