Proximity-induced pharmacology for amyloid-related diseases<br />

dc.contributor.authorBertran-Mostazo, Andrea
dc.contributor.authorPutriute, Gabrielé
dc.contributor.authorÁlvarez-Berbel, Irene
dc.contributor.authorBusquets i Viñas, Ma. Antonia
dc.contributor.authorGaldeano Cantador, Carlos
dc.contributor.authorEspargaró Colomé, Alba
dc.contributor.authorSabaté Lagunas, Raimon
dc.date.accessioned2024-10-21T10:49:16Z
dc.date.available2024-10-21T10:49:16Z
dc.date.issued2024-03-04
dc.date.updated2024-10-21T10:49:16Z
dc.description.abstract<p>Proximity-induced pharmacology (PIP) for amyloid-related diseases is a cutting-edge</p><p>approach to treating conditions such as Alzheimer’s disease and other forms of dementia. By bringing</p><p>small molecules close to amyloid-related proteins, these molecules can induce a plethora of effects</p><p>that can break down pathogenic proteins and reduce the buildup of plaques. One of the most</p><p>promising aspects of this drug discovery modality is that it can be used to target specific types of</p><p>amyloid proteins, such as the beta-amyloid protein that is commonly associated with Alzheimer’s</p><p>disease. This level of specificity could allow for more targeted and effective treatments. With ongoing</p><p>research and development, it is hoped that these treatments can be refined and optimized to provide</p><p>even greater benefits to patients. As our understanding of the underlying mechanisms of these</p><p>diseases continues to grow, proximity-induced pharmacology treatments may become an increasingly</p><p>important tool in the fight against dementia and other related conditions.</p>
dc.format.extent1 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec746915
dc.identifier.issn2073-4409
dc.identifier.urihttps://hdl.handle.net/2445/215920
dc.language.isoeng
dc.publisherMDPI
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.3390/cells13050449
dc.relation.ispartofCells, 2024, vol. 13
dc.relation.urihttps://doi.org/10.3390/cells13050449
dc.rightscc-by (c) Bertran-Mostazo, A. et al., 2024
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceArticles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
dc.subject.classificationMalalties neurodegeneratives
dc.subject.classificationAmiloïdosi
dc.subject.classificationDisseny de medicaments
dc.subject.otherNeurodegenerative Diseases
dc.subject.otherAmyloidosis
dc.subject.otherDrug design
dc.titleProximity-induced pharmacology for amyloid-related diseases<br />
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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