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2016-09-20

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cc-by (c) Ripollés, P. et al., 2016
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/107568

Intrinsic monitoring of learning success facilitates memory encoding via the activation of the SN/VTA-Hippocampal loop

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Recurs relacionat

https://doi.org/10.7554/eLife.17441

Resum

Humans constantly learn in the absence of explicit rewards. However, the neurobiological mechanisms supporting this type of internally-guided learning (without explicit feedback) are still unclear. Here, participants who completed a task in which no external reward/feedback was provided, exhibited enhanced fMRI-signals within the dopaminergic midbrain, hippocampus, and ventral striatum (the SN/VTA-Hippocampal loop) when successfully grasping the meaning of new-words. Importantly, new-words that were better remembered showed increased activation and enhanced functional connectivity between the midbrain, hippocampus, and ventral striatum. Moreover, enhanced emotion-related physiological measures and subjective pleasantness ratings during encoding were associated with remembered new-words after 24 hr. Furthermore, increased subjective pleasantness ratings were also related to new-words remembered after seven days. These results suggest that intrinsic-potentially reward-related-signals, triggered by self-monitoring of correct performance, can promote the storage of new information into long-term memory through the activation of the SN/VTA-Hippocampal loop, possibly via dopaminergic modulation of the midbrain.

Matèries

Hipocamp (Cervell), Memòria, Dopamina, Imatges per ressonància magnètica

Matèries (anglès)

Hippocampus (Brain), Memory, Dopamine, Magnetic resonance imaging

Citació

Col·leccions

Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

RIPOLLÉS, Pablo, MARCO PALLARÉS, Josep, ALICART, Helena, TEMPELMANN, Claus, RODRÍGUEZ FORNELLS, Antoni, NOESSELT, Toemme. Intrinsic monitoring of learning success facilitates memory encoding via the activation of the SN/VTA-Hippocampal loop. _eLife_. 2016. Vol. 5:e17441, núm. 1-35. [consulta: 10 de gener de 2026]. ISSN: 2050-084X. [Disponible a: https://hdl.handle.net/2445/107568]

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