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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/189186
Genetic control of neuronal activity enhances axonal growth only on permissive substrates
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Abstract
Background
Neural tissue has limited regenerative ability. To cope with that, in recent years a diverse set of novel tools has been used to tailor neurostimulation therapies and promote functional regeneration after axonal injuries.
Method
In this report, we explore cell-specific methods to modulate neuronal activity, including opto- and chemogenetics to assess the effect of specific neuronal stimulation in the promotion of axonal regeneration after injury.
Results
Opto- and chemogenetic stimulations of neuronal activity elicited increased in vitro neurite outgrowth in both sensory and cortical neurons, as well as in vivo regeneration in the sciatic nerve, but not after spinal cord injury. Mechanistically, inhibitory substrates such as chondroitin sulfate proteoglycans block the activity induced increase in axonal growth.
Conclusions
We found that genetic modulations of neuronal activity on both dorsal root ganglia and corticospinal motor neurons increase their axonal growth capacity but only on permissive environments.
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Citació
Mesquida-Veny, Francina;Martínez-Torres, Sara;del Rio, Jose Antonio;Hervera, Arnau. Genetic control of neuronal activity enhances axonal growth only on permissive substrates. Molecular Medicine, 2022, 28, 1-97
Citació
MESQUIDA VENY, Francina, MARTÍNEZ TORRES, Sara, DEL RÍO, José antonio, HERVERA, Arnau. Genetic control of neuronal activity enhances axonal growth only on permissive substrates. _Molecular Medicine_. 2022. Vol. 28, núm. 1-97. [consulta: 24 de gener de 2026]. ISSN: 1528-3658. [Disponible a: https://hdl.handle.net/2445/189186]