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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/161870
Hydrogen bonding versus π-interactions: their key competition in sildenafil solvates
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Herein we report the X-ray characterization of four sildenafil solvates where the conformation of the pyrazolo[3,4-d]pyrimidine and phenyl rings depends on the solvent. It conditions the formation of an apparently innocent intramolecular H-bond that has a remarkable influence on the solid state architecture of the sildenafil solvates. DFT calculations indicate that a delicate balance between the energies of H-bonding and π-π (or lp-π) interactions are crucial.
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BARBAS CAÑERO, Rafael, et al. Hydrogen bonding versus π-interactions: their key competition in sildenafil solvates. Crystengcomm. 2018. Vol. 20, num. 32, pags. 4526-4530. ISSN 1466-8033. [consulted: 7 of October of 2026]. Available at: https://hdl.handle.net/2445/161870