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Published version

Publication date

2023-01-03

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cc-by (c) Trejo, Angela et al., 2023
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/194162

Efficient AntiMycolata agents by increasing the lipophilicity of known antibiotics through multicomponent reactions

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https://doi.org/10.3390/antibiotics12010083

Abstract

New antibiotic agents were prepared using Povarov and Ugi multicomponent reactions upon the known drugs sulfadoxine and dapsone. The prepared derivatives, with increased lipophilicity, showed improved efficiency against Mycolata bacteria. Microbiological guidance for medicinal chemistry is a powerful tool to design new and effective antimicrobials. In this case, the readily synthesized compounds open new possibilities in the search for antimicrobials active on mycolic acid-containing bacteria.

Subject

Antibiòtics, Medicaments, Micobacteris

Subject (English)

Antibiotics, Drugs, Mycobacteria

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Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

TREJO, Angela, et al. Efficient AntiMycolata agents by increasing the lipophilicity of known antibiotics through multicomponent reactions. Antibiotics. 2023. Vol. 12, num. 83. ISSN 2079-6382. [consulted: 11 of June of 2026]. Available at: https://hdl.handle.net/2445/194162

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