Efficient AntiMycolata agents by increasing the lipophilicity of known antibiotics through multicomponent reactions

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dc.contributor.authorTrejo, Angela
dc.contributor.authorMasdeu, Carme
dc.contributor.authorSerrano-Pérez, Irene
dc.contributor.authorPedrola, Marina
dc.contributor.authorJuanola, Narcís
dc.contributor.authorGhashgaei, Ouldouz
dc.contributor.authorJiménez Galisteo, Mª Guadalupe
dc.contributor.authorLavilla Grífols, Rodolfo
dc.contributor.authorPalacios, Francisco
dc.contributor.authorAlonso, Concepción
dc.contributor.authorViñas, Miquel
dc.date.accessioned2023-02-24T18:41:57Z
dc.date.available2023-02-24T18:41:57Z
dc.date.issued2023-01-03
dc.date.updated2023-02-24T18:41:57Z
dc.description.abstractNew antibiotic agents were prepared using Povarov and Ugi multicomponent reactions upon the known drugs sulfadoxine and dapsone. The prepared derivatives, with increased lipophilicity, showed improved efficiency against Mycolata bacteria. Microbiological guidance for medicinal chemistry is a powerful tool to design new and effective antimicrobials. In this case, the readily synthesized compounds open new possibilities in the search for antimicrobials active on mycolic acid-containing bacteria.
dc.format.extent14 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec727886
dc.identifier.issn2079-6382
dc.identifier.pmid36671284
dc.identifier.urihttps://hdl.handle.net/2445/194162
dc.language.isoeng
dc.publisherMDPI
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.3390/antibiotics12010083
dc.relation.ispartofAntibiotics, 2023, vol. 12, p. 83
dc.relation.urihttps://doi.org/10.3390/antibiotics12010083
dc.rightscc-by (c) Trejo, Angela et al., 2023
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceArticles publicats en revistes (Patologia i Terapèutica Experimental)
dc.subject.classificationAntibiòtics
dc.subject.classificationMedicaments
dc.subject.classificationMicobacteris
dc.subject.otherAntibiotics
dc.subject.otherDrugs
dc.subject.otherMycobacteria
dc.titleEfficient AntiMycolata agents by increasing the lipophilicity of known antibiotics through multicomponent reactions
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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