Miniatura

Fitxers

698688.pdf (992.67 KB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2019-04-27

Llicència de publicació

cc-by (c) Vitelli Storelli, Facundo et al., 2019
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/171674

Flavonoids and the risk of gastric cancer: an exploratory case-control study in the MCC-Spain Study

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.3390/nu11050967

Resum

Several epidemiological studies have investigated the association between the dietary flavonoid intake and gastric cancer (GC) risk; however, the results remain inconclusive. Investigating the relationship between the different classes of flavonoids and the histological types and origin of GC can be of interest to the research community. We used data from a population-based multi-case control study (MCC-Spain) obtained from 12 different regions of Spain. 2700 controls and 329 GC cases were included in this study. Odds ratios (ORs) were calculated using the mixed effects logistic regression considering quartiles of flavonoid intakes and log2. Flavonoid intake was associated with a lower GC risk (ORlog2 = 0.76; 95% CI = 0.65-0.89; ORq4vsq1 = 0.60; 95%CI = 0.40-0.89; ptrend = 0.007). Inverse and statistically significant associations were observed with anthocyanidins, chalcones, dihydroflavonols and flavan-3-ols. The isoflavanoid intake was positively associated with higher cancer risk, but without reaching a statistical significance. In general, no differences were observed in the GC risk according to the location and histological type. The flavonoid intake seems to be a protective factor against GC within the MCC-study. This effect may vary depending on the flavonoid class but not by the histological type and location of the tumor. Broader studies with larger sample size and greater geographical variability are necessary.

Matèries

Dieta, Flavonoides, Farmacologia, Càncer d'estómac

Matèries (anglès)

Diet, Flavonoids, Pharmacology, Stomach cancer

Citació

Col·leccions

Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)

Citació

VITELLI STORELLI, Facundo, MOLINA DE LA TORRE, Antonio josé, ZAMORA-ROS, Raul, FERNÁNDEZ VILLA, Tania, ROUSSOU, Vasiliki, ROMAGUERA, Dora, ARAGONÈS SANZ, Núria, OBÓN SANTACANA, Mireia, GUEVARA, Marcela, GÓMEZ ACEBO, Inés, FERNÁNDEZ TARDÓN, Guillermo, MOLINA BARCELÓ, Ana, OLMEDO REQUENA, Rocío, CAPELO ÁLVAREZ, Rocío, CHIRLAQUE, María dolores, PÉREZ GÓMEZ, Beatriz, MORENO AGUADO, Víctor, CASTILLA, Jesús, RUBÍN GARCÍA, María, POLLÁN, Marina, KOGEVINAS, Manolis, BARRIO LERA, Juan pablo, MARTÍN SÁNCHEZ, Vicente. Flavonoids and the risk of gastric cancer: an exploratory case-control study in the MCC-Spain Study. _Nutrients_. 2019. Vol. 11, núm. 5, pàgs. 967. [consulta: 9 de gener de 2026]. ISSN: 2072-6643. [Disponible a: https://hdl.handle.net/2445/171674]

Exportar metadades

JSON - METS

Compartir registre