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Article

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Published version

Publication date

2014-09-12

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cc-by (c) Williams, James P. et al., 2014
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/117328

HIV-1 DNA predicts disease progression and post-treatment virological control

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https://doi.org/10.7554/eLife.03821

Abstract

In HIV-1 infection, a population of latently infected cells facilitates viral persistence despite antiretroviral therapy (ART). With the aim of identifying individuals in whom ART might induce a period of viraemic control on stopping therapy, we hypothesised that quantification of the pool of latently infected cells in primary HIV-1 infection (PHI) would predict clinical progression and viral replication following ART. We measured HIV-1 DNA in a highly characterised randomised population of individuals with PHI. We explored associations between HIV-1 DNA and immunological and virological markers of clinical progression, including viral rebound in those interrupting therapy. In multivariable analyses, HIV-1 DNA was more predictive of disease progression than plasma viral load and, at treatment interruption, predicted time to plasma virus rebound. HIV-1 DNA may help identify individuals who could safely interrupt ART in future HIV-1 eradication trials.

Subject

VIH (Virus), Antiretrovirals, Malalties infeccioses, Assaigs clínics

Subject (English)

HIV (Viruses), Antiretroviral agents, Communicable diseases, Clinical trials

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Articles publicats en revistes (Medicina)

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WILLIAMS, James P., et al. HIV-1 DNA predicts disease progression and post-treatment virological control. eLife. 2014. Vol. 3, num. e03821. ISSN 2050-084X. [consulted: 10 of August of 2026]. Available at: https://hdl.handle.net/2445/117328

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