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2017-05-22

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/126243

Hepcidin levels and gastric cancer risk in the EPIC-EurGast Study

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https://doi.org/10.1002/ijc.30797

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Hepcidin is the main regulator of iron homeostasis and dysregulation of proteins involved in iron metabolism has been associated with tumorogenesis. However, to date, no epidemiological study has researched the association between hepcidin levels and gastric cancer risk. To further investigate the relationship between hepcidin levels and gastric cancer risk, we conducted a nested case‐control study (EURGAST) within the multicentric European Prospective Investigation into Cancer and Nutrition study. The study included 456 primary incident gastric adenocarcinoma cases and 900 matched controls that occurred during an average of 11 years of follow‐up. We measured serum levels of hepcidin‐25, iron, ferritin, transferrin and C‐reactive protein. Odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of gastric cancer by hepcidin levels were estimated from multivariable conditional logistic regression models. Mediation effect of the ferritin levels on the hepcidin‐gastric cancer pathway was also evaluated. After adjusting for relevant confounders, we observed a statistically significant inverse association between gastric cancer and hepcidin levels (OR 5 ng/l = 0.96, 95% CI = 0.93-0.99). No differences were found by tumor localization or histological type. In mediation analysis, we found that the direct effect of hepcidin only represents a nonsignificant 38% (95% CI: −69%, 91%). In summary, these data suggest that the inverse association of hepcidin levels and gastric cancer risk was mostly accounted by ferritin levels. Further investigation including repeated measures of hepcidin is needed to clarify their role in gastric carcinogenesis.

Matèries

Càncer, Aparell digestiu, Homeòstasi

Matèries (anglès)

Cancer, Digestive organs, Homeostasis

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Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

JAKSZYN, Paula, FONSECA-NUÑES, Anna, LUJÁN BARROSO, Leila, ARANDA, Núria, TOUS, Mónica, ARIJA VAL, Victoria, CROSS, Amanda j., BUENO DE MESQUITA, H. bas, WEIDERPASS, Elisabete, KÜHN, Tilman, KAAKS, Rudolf, SJÖBERG, Klas, OHLSSON, Bodil, TUMINO, Rosario, PALLI, Domenico, RICCERI, Fulvio, FASANELLI, Francesca, KROGH, Vittorio, MATTIELLO, Amalia, JENAB, Mazda, GUNTER, Marc j., PÉREZ CORNAGO, Aurora, KHAW, Kay-tee, TJØNNELAND, Anne, OLSEN, Anja, OVERVAD, Kim, TRICHOPOULOU, Antonia, PEPPA, Eleni, VASILOPOULOU, Effie, BOEING, Heiner, SÁNCHEZ CANTALEJO, Emilio, HUERTA CASTAÑO, José maría, DORRONSORO, Miren, BARRICARTE, Aurelio, QUIRÓS, José maria, PEETERS, Petra h. m., AGUDO, Antonio. Hepcidin levels and gastric cancer risk in the EPIC-EurGast Study. _International Journal of Cancer_. 2017. Vol. 141, núm. 945-951. [consulta: 23 de gener de 2026]. ISSN: 0020-7136. [Disponible a: https://hdl.handle.net/2445/126243]

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