Miniatura

Fitxers

729900.pdf (371.45 KB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2022-12-01

Llicència de publicació

(c) Bullón Vela, Vanessa et al., 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/193992

Health associations of liver enzymes and inflammatory scores with urinary citrus flavonoid metabolites

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1039/d2fo02846h

Resum

Background: Dietary flavonoid intake is associated with a reduced risk of some cardiometabolic disorders, attributed in part to their claimed anti-inflammatory activity. Our aim was to investigate the potential association between specific urine flavonoid metabolites, liver enzymes, and inflammatory status in individuals with metabolic syndrome (MetS). Methods: In this cross-sectional study, clinical and dietary data from 267 participants, aged 55 to 75 years, participating in the PREDIMED Plus study (PREvención con DIeta MEDiterránea) were analyzed. At the baseline, spot urine samples were collected and seven urinary flavonoid metabolites were quantified using ultra-performance liquid chromatography coupled to triple quadrupole mass spectrometry (UPLC-Q-q-Q MS). Liver enzymes, inflammatory scores, and urinary flavonoid concentrations were inverse normally transformed. Results: Adjusted linear regression models showed an inverse association between urinary citrus flavanone concentrations and gamma-glutamyl transferase (GGT) (all p-values <0.05). Naringenin 7'-GlcUA was significantly associated with a lower aggregate index of systemic inflammation (AISI) (Bper 1SD = -0.14; 95% CI: -0.27 to -0.02; p-value = 0.025) and systemic inflammation index (SII) (Bper 1SD = -0.14; 95% CI: -0.27 to -0.02; p-value = 0.028). To investigate the relationship between flavanone subclasses and GGT levels, we fitted a score of citrus-flavanones, and subjects were stratified into quartiles. The highest values of the citrus-flavanone score (per 1-SD increase) were associated with lower GGT levels (Bper 1SD = -0.41; 95% CI: -0.74 to -0.07), exhibiting a linear trend across quartiles (p-trend = 0.015). Conclusion: This cross-sectional study showed that higher urinary excretion of citrus-flavanone metabolites was associated with lower GGT levels in subjects diagnosed with MetS and obesity.

Matèries

Malalties del fetge, Flavonoides

Matèries (anglès)

Liver diseases, Flavonoids

Citació

Col·leccions

Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

BULLÓN VELA, Vanessa, XU, Yifan, RAZQUIN, Cristina, ABETE, Itziar, ZULET, M. angeles, MARTÍNEZ-GONZÁLEZ, Miguel ángel, BUIL COSIALES, Pilar, VITELLI STORELLI, Facundo, MARTÍN SÁNCHEZ, Vicente, VÁZQUEZ RUIZ, Zenaida, SAYÓN OREA, Carmen, DOMÍNGUEZ-FERNÁNDEZ, Maite, CID, Concepción, ESTRUCH RIBA, Ramon, LAMUELA RAVENTÓS, Rosa ma., FITÓ COLOMER, Montserrat, BLANCHART, Gemma, BABIO, Nancy, SALAS SALVADÓ, Jordi, TINAHONES, Francisco j., TUR, Josep antoni, ROMAGUERA, Dora, KONIECZNA, Jadwiga, PINTÓ SALA, Xavier, DAIMIEL, Lidia, RODRÍGUEZ-MATEOS, Ana, MARTÍNEZ, José alfredo. Health associations of liver enzymes and inflammatory scores with urinary citrus flavonoid metabolites. _Food & Function_. 2022. [consulta: 26 de febrer de 2026]. ISSN: 2042-6496. [Disponible a: https://hdl.handle.net/2445/193992]

Exportar metadades

JSON - METS

Compartir registre