Document type
ArticleVersion
Published versionPublication date
Publication license
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/56766
Microstructural Brain Differences Predict Functional Hemodynamic Responses in a Reward Processing Task
Journal Title
Director/Tutor
Additional contribution
Journal ISSN
Volume Title
Abstract
Many aspects of human behavior are driven by rewards, yet different people are differentially sensitive to rewards and punishment. In this study, we showthat white matter microstructure inthe uncinate/inferiorfronto-occipitalfasciculus, defined byfractional anisotropy values derived from diffusion tensor magnetic resonance images, correlates with both short-term (indexed by the fMRI blood oxygenation level-dependent response to reward in the nucleus accumbens) and long-term (indexed by the trait measure sensitivity to punishment) reactivityto rewards.Moreover,traitmeasures of reward processingwere also correlatedwith reward-relatedfunctional activation in the nucleus accumbens. The white matter tract revealed by the correlational analysis connects the anterior temporal lobe with the medial and lateral orbitofrontal cortex and also supplies the ventral striatum. The pattern of strong correlations suggests an intimate relationship betweenwhitematter structure and reward-related behaviorthatmay also play a rolein a number of pathological conditions, such as addiction and pathological gambling.
Related resource
Subject
Subject (English)
Citation
Citation
CÀMARA, Estela, RODRÍGUEZ FORNELLS, Antoni and MÜNTE, Thomas F. Microstructural Brain Differences Predict Functional Hemodynamic Responses in a Reward Processing Task. Journal of Neuroscience. 2010. Vol. 30, num. 34, pags. 11398-11402. ISSN 0270-6474. [consulted: 8 of October of 2026]. Available at: https://hdl.handle.net/2445/56766