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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/126171
A genome-wide association study of marginal zone lymphoma shows association to the HLA region
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Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P - 3.95 x 10(-15)) and HLA-B (rs2922994, P - 2.43 x 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
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VIJAI, Joseph, WANG, Zhaoming, BERNDT, Sonja i., SKIBOLA, Christine f., SLAGER, Susan l., SANJOSÉ LLONGUERAS, Silvia de, MELBYE, Mads, GLIMELIUS, Bengt, BRACCI, Paige m., CONDE, Lucía, BIRMANN, Brenda m., DIVER, W. ryan, VAJDIC, Claire m., ARMSTRONG, Bruce k., KRICKER, Anne, ZHENG, Tongzhang, HOLFORD, Theodore r., SEVERI, Gianluca, VINEIS, Paolo, FERRI, Giovanni m., RICCO, Rosalia, MILIGI, Lucia, CLAVEL, Jacqueline, GIOVANNUCCI, Edward l., KRAFT, Peter, VIRTAMO, Jarmo, SMITH, Alex, KANE, Eleanor, ROMAN, Eve, CHIU, Brian c. h., FRAUMENI, Joseph f., WU, Xifeng, CERHAN, James r., OFFIT, Kenneth, CHANOCK, Stephen j., ROTHMAN, Nathaniel, NIETERS, Alexandra, WANG, Sophia s., BROOKS-WILSON, Angela r., LAN, Qing, BAKKER, Paul i. w. de, VERMEULEN, Roel c. h., PORTLOCK, Carol, ANSELL, Stephen m., LINK, Brian k., RIBY, Jacques, NORTH, Kari e., GU, Jian, HJALGRIM, Henrik, COZEN, Wendy, BECKER, Nikolaus, TERAS, Lauren r., SPINELLI, John j., TURNER, Jenny, ZHANG, Yawei, PURDUE, Mark p., GILES, Graham g., KELLY, Rachel s., ZELENIUCH-JACQUOTTE, Anne, ENNAS, Maria grazia, MONNEREAU, Alain, BERTRAND, Kimberly a., ALBANES, Demetrius, LIGHTFOOT, Tracy, YEAGER, Meredith, CHUNG, Charles c., BURDETT, Laurie, HUTCHINSON, Amy, LAWRENCE, Charles, MONTALVAN, Rebecca, LIANG, Liming, HUANG, Jinyan, MA, Baoshan, VILLANO, Danylo j., MARIA, Ann, CORINES, Marina, THOMAS, Tinu, NOVAK, Anne j., DOGAN, Ahmet, LIEBOW, Mark, THOMPSON, Carrie a., WITZIG, Thomas e., HABERMANN, Thomas m., WEINER, George j., SMITH, Martyn t., HOLLY, Elizabeth a., JACKSON, Rebecca d. j., TINKER, Lesley f., YE, Yuanqing, ADAMI, Hans-olov, SMEDBY, Karin e., ROOS, Anneclaire j. de, HARTGE, Patricia, MORTON, Lindsay m., SEVERSON, Richard k., BENAVENTE, Yolanda, BOFFETTA, Paolo, BRENNAN, Paul, FORETOVA, Lenka, MAYNADIÉ, Marc, MCKAY, James d., STAINES, Anthony. A genome-wide association study of marginal zone lymphoma shows association to the HLA region. _Nature Communications_. 2015. Vol. 6. [consulta: 24 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/126171]