Spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes

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dc.contributor.authorTarifa, Carmen
dc.contributor.authorVallmitjana, Alexander
dc.contributor.authorJiménez Sábado, Verónica
dc.contributor.authorMarchena, Miquel
dc.contributor.authorLlach, Anna
dc.contributor.authorHerraiz Martínez, Adela
dc.contributor.authorGodoy-Marín, Héctor
dc.contributor.authorNolla-Colomer, Carme
dc.contributor.authorGinel, Antonino
dc.contributor.authorViñolas, Xavier
dc.contributor.authorMontiel, José
dc.contributor.authorCiruela Alférez, Francisco
dc.contributor.authorEchebarria, Blas
dc.contributor.authorBenitez, Raúl
dc.contributor.authorCinca, Juan
dc.contributor.authorHove-Madsen, Leif
dc.date.accessioned2023-09-21T17:07:39Z
dc.date.available2023-09-21T17:07:39Z
dc.date.issued2023-02-01
dc.date.updated2023-09-21T17:07:39Z
dc.description.abstractAnalysis of the spatio-temporal distribution of calcium sparks showed a preferential increase in sparks near the sarcolemma in atrial myocytes from patients with atrial fibrillation (AF), linked to higher ryanodine receptor (RyR2) phosphorylation at s2808 and lower calsequestrin-2 levels. Mathematical modeling, incorporating modulation of RyR2 gating, showed that only the observed combinations of RyR2 phosphorylation and calsequestrin-2 levels can account for the spatio-temporal distribution of sparks in patients with and without AF. Furthermore, we demonstrate that preferential calcium release near the sarcolemma is key to a higher incidence and amplitude of afterdepolarizations in atrial myocytes from patients with AF
dc.format.extent15 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec732318
dc.identifier.issn2452-302X
dc.identifier.pmid36777175
dc.identifier.urihttps://hdl.handle.net/2445/202167
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1016/j.jacbts.2022.07.013
dc.relation.ispartofJACC: Basic to Translational Science, 2023, vol. 8, num. 1, p. 1-15
dc.relation.urihttps://doi.org/10.1016/j.jacbts.2022.07.013
dc.rightscc-by (c) Tarifa, Carmen et al., 2023
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceArticles publicats en revistes (Patologia i Terapèutica Experimental)
dc.subject.classificationFibril·lació auricular
dc.subject.classificationCèl·lules musculars
dc.subject.classificationCanals de calci
dc.subject.otherAtrial fibrillation
dc.subject.otherMuscle cells
dc.subject.otherCalcium channels
dc.titleSpatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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