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2023-02-01

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cc-by (c) Tarifa, Carmen et al., 2023
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/202167

Spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes

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https://doi.org/10.1016/j.jacbts.2022.07.013

Abstract

Analysis of the spatio-temporal distribution of calcium sparks showed a preferential increase in sparks near the sarcolemma in atrial myocytes from patients with atrial fibrillation (AF), linked to higher ryanodine receptor (RyR2) phosphorylation at s2808 and lower calsequestrin-2 levels. Mathematical modeling, incorporating modulation of RyR2 gating, showed that only the observed combinations of RyR2 phosphorylation and calsequestrin-2 levels can account for the spatio-temporal distribution of sparks in patients with and without AF. Furthermore, we demonstrate that preferential calcium release near the sarcolemma is key to a higher incidence and amplitude of afterdepolarizations in atrial myocytes from patients with AF

Subject

Fibril·lació auricular, Cèl·lules musculars, Canals de calci

Subject (English)

Atrial fibrillation, Muscle cells, Calcium channels

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Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

TARIFA, Carmen, et al. Spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes. JACC: Basic to Translational Science. 2023. Vol. 8, num. 1, pags. 1-15. ISSN 2452-302X. [consulted: 15 of August of 2026]. Available at: https://hdl.handle.net/2445/202167

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