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2017-08

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/165151

A low-protein diet induces body weight loss and browning of subcutaneous white adipose tissue through enhanced expression of hepatic Fibroblast Growth Factor 21 (FGF21).

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https://doi.org/10.1002/mnfr.201600725

Resum

Scope: Fibroblast growth factor 21 (FGF21) is considered a promising therapeutic candidate for the treatment of obesity. Since FGF21 production is regulated by various nutritional factors, we analyze the impact of low protein intake on circulating levels of this growth hormone in mice and in a sub cohort of the PREDIMED (Prevención con Dieta Mediterránea) trial. We also describe the role of hepatic FGF21 in metabolic adaptation to a low-protein diet (LPD). Methods and results: We fed control and liver-specific Fgf21 knockout (LFgf21KO) mice a LPD. This diet increased FGF21 production by inducing its overexpression in liver, and this correlated with a body weight decrease without changes in food intake. The LPD also caused FGF21-dependent browning in subcutaneous white adipose tissue (scWAT), as indicated by an increase in the expression of uncoupling protein 1 (UCP1). In a subgroup of 78 individuals from the PREDIMED trial, we observed an inverse correlation between protein intake and circulating FGF21 levels. Conclusions: Our results reinforce the involvement of FGF21 in coordinating energy homeostasis under a range of nutritional conditions. Moreover, here we describe an approach to increase the endogenous production of FGF21, which if demonstrated functional in humans, could generate a treatment for obesity.

Matèries

Teixit adipós, Fisiologia, Obesitat, Aprimament, Expressió gènica, Homeòstasi, Vellesa

Matèries (anglès)

Adipose tissues, Physiology, Obesity, Weight loss, Gene expression, Homeostasis, Old age

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Col·leccions

Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut de Biomedicina (IBUB))
Articles publicats en revistes (Institut de Recerca en Nutrició i Seguretat Alimentària (INSA·UB))
Articles publicats en revistes (Medicina)

Citació

PÉREZ MARTÍ, Albert, GARCIA-GUASCH, Maite, TRESSERRA I RIMBAU, Anna, CARRILHO DO ROSÁRIO, Alexandra, ESTRUCH RIBA, Ramon, SALAS SALVADÓ, Jordi, MARTÍNEZ-GONZÁLEZ, Miguel ángel, LAMUELA RAVENTÓS, Rosa ma., MARRERO GONZÁLEZ, Pedro f., HARO BAUTISTA, Diego, RELAT PARDO, Joana. A low-protein diet induces body weight loss and browning of subcutaneous white adipose tissue through enhanced expression of hepatic Fibroblast Growth Factor 21 (FGF21).. _Molecular Nutrition & Food Research_. 2017. Vol. 61, núm. 8, pàgs. 1600725. [consulta: 23 de gener de 2026]. ISSN: 1613-4125. [Disponible a: https://hdl.handle.net/2445/165151]

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