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2017-08

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/165151

A low-protein diet induces body weight loss and browning of subcutaneous white adipose tissue through enhanced expression of hepatic Fibroblast Growth Factor 21 (FGF21).

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https://doi.org/10.1002/mnfr.201600725

Abstract

Scope: Fibroblast growth factor 21 (FGF21) is considered a promising therapeutic candidate for the treatment of obesity. Since FGF21 production is regulated by various nutritional factors, we analyze the impact of low protein intake on circulating levels of this growth hormone in mice and in a sub cohort of the PREDIMED (Prevención con Dieta Mediterránea) trial. We also describe the role of hepatic FGF21 in metabolic adaptation to a low-protein diet (LPD). Methods and results: We fed control and liver-specific Fgf21 knockout (LFgf21KO) mice a LPD. This diet increased FGF21 production by inducing its overexpression in liver, and this correlated with a body weight decrease without changes in food intake. The LPD also caused FGF21-dependent browning in subcutaneous white adipose tissue (scWAT), as indicated by an increase in the expression of uncoupling protein 1 (UCP1). In a subgroup of 78 individuals from the PREDIMED trial, we observed an inverse correlation between protein intake and circulating FGF21 levels. Conclusions: Our results reinforce the involvement of FGF21 in coordinating energy homeostasis under a range of nutritional conditions. Moreover, here we describe an approach to increase the endogenous production of FGF21, which if demonstrated functional in humans, could generate a treatment for obesity.

Subject

Teixit adipós, Fisiologia, Obesitat, Aprimament, Expressió gènica, Homeòstasi, Vellesa

Subject (English)

Adipose tissues, Physiology, Obesity, Weight loss, Gene expression, Homeostasis, Old age

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Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut de Biomedicina (IBUB))
Articles publicats en revistes (Institut de Recerca en Nutrició i Seguretat Alimentària (INSA·UB))
Articles publicats en revistes (Medicina)

Citation

PÉREZ MARTÍ, Albert, et al. A low-protein diet induces body weight loss and browning of subcutaneous white adipose tissue through enhanced expression of hepatic Fibroblast Growth Factor 21 (FGF21). Molecular Nutrition & Food Research. 2017. Vol. 61, num. 8, pags. 1600725. ISSN 1613-4125. [consulted: 8 of June of 2026]. Available at: https://hdl.handle.net/2445/165151

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