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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/197180
Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients
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Background:The role of allergen sensitization in IL-31 production by T cells and specifically in the clinical context of atopic dermatitis (AD) has not been characterized. MethodsThe response to house dust mite (HDM) in purified memory T cells cocultured with epidermal cells from AD patients (n=58) and control subjects (n=11) was evaluated. AD-associated cytokines from culture supernatants, plasma proteins and mRNA expression from cutaneous lesions were assessed and related with the clinical features of the patients. ResultsHDM-induced IL-31 production by memory T cells defined two subsets of AD patients according to the presence or absence of IL-31 response. Patients in the IL-31 producing group showed a more inflammatory profile, and increased HDM-specific (sp) and total IgE levels compared to the IL-31 non-producing group. A correlation between IL-31 production and patient's pruritus intensity, plasma CCL27 and periostin was detected. When the same patients were analyzed based on sp IgE and total IgE levels, an increased IL-31 in vitro response, as well as type 2 markers in plasma and cutaneous lesions, was found in patients with sp IgE levels > 100 kUA/L and total IgE levels > 1000 kU/L. The IL-31 response by memory T cells was restricted to the cutaneous lymphocyte-associated antigen (CLA)(+) T-cell subset. ConclusionIgE sensitization to HDM allows stratifying IL-31 production by memory T cells in AD patients and relating it to particular clinical phenotypes of the disease.
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SANS DE SAN NICOLÀS, Lídia, FIGUERAS NART, Ignasi, GARCÍA-JIMÉNEZ, Irene, BONFILL ORTÍ, Montserrat, GUILABERT, Antonio, CURTO BARREDO, Laia, BERTOLÍN COLILLA, Marta, FERRAN, Marta, SERRA BALDRICH, Esther, PUJOL, Ramon m., SANTAMARIA BABÍ, Luis f.. Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients. _Frontiers in Immunology_. 2023. Vol. 14, núm. 1124018. [consulta: 21 de gener de 2026]. ISSN: 1664-3224. [Disponible a: https://hdl.handle.net/2445/197180]