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2020

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/173621

Short time guided bone regeneration using beta-tricalcium phosphate with and without fibronectin. An experimental study in rats

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Recurs relacionat

https://doi.org/10.4317/medoral.23564

Resum

Background: The aim of this histomorphometric study was to assess the bone regeneration potential of beta-tricalcium phosphate with fibronectin (β-TCP-Fn) in critical-sized defects (CSDs) in rats calvarial, to know whether Fn improves the new bone formation in a short time scope. Material and Methods: CSDs were created in 30 Sprague Dawley rats, and divided into four groups (2 or 6 weeks of healing) and type of filling (β-TCP-Fn, β-TCP, empty control). Variables studied were augmented area (AA), gained tissue (GT), mineralized/non mineralized bone matrix (MBM/NMT) and bone substitute (BS). Results: 60 samples at 2 and six weeks were evaluated. AA was higher for treatment groups comparing to controls (p < 0.001) and significant decrease in BS area in the β-TCP-Fn group from 2 to 6 weeks (p = 0.031). GT was higher in the β-TCP-Fn group than in the controls expressed in % (p = 0.028) and in mm2 (p = 0.011), specially at two weeks (p=0.056). Conclusions: Both β-TCP biomaterials are effective as compared with bone defects left empty in maintaining the volume. GT in defects regeneration filed with β-TCP-Fn are significantly better in short healing time when comparing with controls but not for β-TCP used alone in rats calvarial CSDs.

Matèries

Regeneració (Biologia), Malalties dels ossos, Rates (Animals de laboratori)

Matèries (anglès)

Regeneration (Biology), Bone diseases, Rats as laboratory animals

Citació

Col·leccions

Articles publicats en revistes (Odontoestomatologia)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

SÁNCHEZ GARCÉS, Ma. Ángeles, et al. Short time guided bone regeneration using beta-tricalcium phosphate with and without fibronectin. An experimental study in rats. Medicina Oral. Patología Oral y Cirugía Bucal. Vol.  2020, num. 25, pags. 4. ISSN 1698-4447. [consulted: 18 of August of 2026]. Available at: https://hdl.handle.net/2445/173621

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