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2020

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/173621

Short time guided bone regeneration using beta-tricalcium phosphate with and without fibronectin. An experimental study in rats

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https://doi.org/10.4317/medoral.23564

Resum

Background: The aim of this histomorphometric study was to assess the bone regeneration potential of beta-tricalcium phosphate with fibronectin (β-TCP-Fn) in critical-sized defects (CSDs) in rats calvarial, to know whether Fn improves the new bone formation in a short time scope. Material and Methods: CSDs were created in 30 Sprague Dawley rats, and divided into four groups (2 or 6 weeks of healing) and type of filling (β-TCP-Fn, β-TCP, empty control). Variables studied were augmented area (AA), gained tissue (GT), mineralized/non mineralized bone matrix (MBM/NMT) and bone substitute (BS). Results: 60 samples at 2 and six weeks were evaluated. AA was higher for treatment groups comparing to controls (p < 0.001) and significant decrease in BS area in the β-TCP-Fn group from 2 to 6 weeks (p = 0.031). GT was higher in the β-TCP-Fn group than in the controls expressed in % (p = 0.028) and in mm2 (p = 0.011), specially at two weeks (p=0.056). Conclusions: Both β-TCP biomaterials are effective as compared with bone defects left empty in maintaining the volume. GT in defects regeneration filed with β-TCP-Fn are significantly better in short healing time when comparing with controls but not for β-TCP used alone in rats calvarial CSDs.

Matèries

Regeneració (Biologia), Malalties dels ossos, Rates (Animals de laboratori)

Matèries (anglès)

Regeneration (Biology), Bone diseases, Rats as laboratory animals

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Articles publicats en revistes (Odontoestomatologia)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

SÁNCHEZ GARCÉS, Ma. Ángeles, et al. Short time guided bone regeneration using beta-tricalcium phosphate with and without fibronectin. An experimental study in rats. Medicina Oral. Patología Oral y Cirugía Bucal. Vol.  2020, num. 25, pags. 4. ISSN 1698-4447. [consulted: 25 of May of 2026]. Available at: https://hdl.handle.net/2445/173621

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