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2025-01

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cc-by-nc-nd (c) Morales, Enrique et al., 2025
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/220652

Recomendaciones para el diagnóstico y tratamiento de las vasculitis asociadas a anticuerpos anticitoplasma de neutrófilo.

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Recurs relacionat

https://doi.org/10.1016/j.nefro.2024.07.004

Resum

Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis is characterised by small vessel necrotising inflammatory vasculitis. Prior to immunosupressant therapy availability it usually led to a fatal outcome. Current treatment has changed ANCA-associated vasculitis into a condition with a significant response rate, although with a not negligible relapse occurrence and cumulative organ lesions, mostly due to drug-related toxicities. The use of glucocorticoids, cyclophosphamide and other immunosupressants (such as azathioprine, mychophenolate and methotrexate) was optimised in a series of clinical trials that established the treatment of reference. In recent years, a better knowledge of B lymphocyte function and the role of complement inhibition has transformed the course of this disease while minimising treatment-related adverse effects. This multidisciplinary document of recommendations is based on the consensus of three scientific societies (Internal Medicine, Nephrology and Rheumatology) and on the best available evidence on diagnosis, treatment and follow-up of patients with ANCA-associated vasculitis, including some special situations. The aim of this document is to provide updated information and well-grounded clinical recommendations to practising physicians as to how to improve the diagnosis and treatment outcome of our patients.

Matèries

Neutròfils, Immunosupressió, Autoanticossos, Inflamació, Vasculitis

Matèries (anglès)

Neutrophils, Immunosuppression, Autoantibodies, Inflammation, Vasculitis

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

MORALES, Enrique, RÚA FIGUEROA, Iñigo, CALLEJAS RUBIO, José luis, ÁVILA BERNABÉU, Ana, BLANCO ALONSO, Ricardo, CID XUTGLÀ, M. cinta, MANRIQUE ESCOLA, Joaquín, NARVÁEZ GARCÍA, Francisco javier, SOPEÑA, Bernardo, QUINTANA PORRAS, Luis f., ROMERO YUSTE, Susana, SOLANS LAQUÉ, Roser. Recomendaciones para el diagnóstico y tratamiento de las vasculitis asociadas a anticuerpos anticitoplasma de neutrófilo.. _Nefrología_. 2025. Vol. 45, núm. 1, pàgs. 15-58. [consulta: 20 de gener de 2026]. ISSN: 0211-6995. [Disponible a: https://hdl.handle.net/2445/220652]

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