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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/174217
Long-Term Use of Tedizolid in Osteoarticular Infections: Benefits among Oxazolidinone Drugs
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Background: To evaluate the efficacy and safety of long-term use of tedizolid in osteoarticular infections. Methods: Multicentric retrospective study (January 2017–March 2019) of osteoarticular
infection cases treated with tedizolid. Failure: clinical worsening despite antibiotic treatment or the
need of suppressive treatment. Results: Cases (n = 51; 59% women, mean age of 65 years) included
osteoarthritis (n = 27, 53%), prosthetic joint infection (n = 17, 33.3%), and diabetic foot infections (n = 9,
18%); where, 59% were orthopedic device-related. Most frequent isolates were Staphylococcus spp.
(65%, n = 47; S. aureus, 48%). Reasons for choosing tedizolid were potential drug-drug interaction
(63%) and cytopenia (55%); median treatment duration was 29 days (interquartile range -IQR- 15–44),
24% received rifampicin (600 mg once daily) concomitantly, and adverse events were scarce (n = 3).
Hemoglobin and platelet count stayed stable throughout treatment (from 108.6 g/L to 116.3 g/L,
p = 0.079; and 240 × 109/L to 239 × 109/L, p = 0.942, respectively), also in the subgroup of cases with
cytopenia. Among device-related infections, 33% were managed with implant retention. Median
follow-up was 630 days and overall cure rate 83%; among failures (n = 8), 63% were device-related
infections. Conclusions: Long-term use of tedizolid was effective, showing a better safety profile with
less myelotoxicity and lower drug-drug interaction than linezolid. Confirmation of these advantages
could make tedizolid the oxazolidinone of choice for most of osteoarticular infections.
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BENAVENT PALOMARES, Eva, et al. Long-Term Use of Tedizolid in Osteoarticular Infections: Benefits among Oxazolidinone Drugs. Antibiotics. 2021. Vol. 10, num. 1. [consulted: 6 of June of 2026]. Available at: https://hdl.handle.net/2445/174217