Miniatura

Fitxers

690022.pdf (853.49 KB)

Tipus de document

Article

Versió

Versió acceptada

Data de publicació

2019-04-04

Tots els drets reservats

Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/174982

Predicting circulating CA125 levels among healthy premenopausal women

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1158/1055-9965.EPI-18-1120

Resum

Background: Cancer antigen 125 (CA125) is the most promising ovarian cancer screening biomarker to date. Multiple studies reported CA125 levels vary by personal characteristics, which could inform personalized CA125 thresholds. However, this has not been well described in premenopausal women. Methods: We evaluated predictors of CA125 levels among 815 premenopausal women from the New England Case Control Study (NEC). We developed linear and dichotomous (≥35 U/mL) CA125 prediction models and externally validated an abridged model restricting to available predictors among 473 premenopausal women in the European Prospective Investigation into Cancer and Nutrition Study (EPIC). Results: The final linear CA125 prediction model included age, race, tubal ligation, endometriosis, menstrual phase at blood draw, and fibroids, which explained 7% of the total variance of CA125. The correlation between observed and predicted CA125 levels based on the abridged model (including age, race, and menstrual phase at blood draw) had similar correlation coefficients in NEC (r = 0.22) and in EPIC (r = 0.22). The dichotomous CA125 prediction model included age, tubal ligation, endometriosis, prior personal cancer diagnosis, family history of ovarian cancer, number of miscarriages, menstrual phase at blood draw, and smoking status with AUC of 0.83. The abridged dichotomous model (including age, number of miscarriages, menstrual phase at blood draw, and smoking status) showed similar AUCs in NEC (0.73) and in EPIC (0.78). Conclusions: We identified a combination of factors associated with CA125 levels in premenopausal women. Impact: Our model could be valuable in identifying healthy women likely to have elevated CA125 and consequently improve its specificity for ovarian cancer screening.

Matèries

Menopausa, Càncer d'ovari, Nutrició

Matèries (anglès)

Menopause, Ovarian cancer, Nutrition

Citació

Col·leccions

Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

SASAMOTO, Naoko, BABIC, Ana, ROSNER, Bernard a., FORTNER, Renée t., VITONIS, Allison f., YAMAMOTO, Hidemi, FICHOROVA, Raina n., TJØNNELAND, Anne, HANSEN, Louise, OVERVAD, Kim, KVASKOFF, Marina, FOURNIER, Agnès, MANCINI, Francesca romana, BOEING, Heiner, TRICHOPOULOU, Antonia, PEPPA, Eleni, KARAKATSANI, Anna, PALLI, Domenico, PALA, Valeria, MATTIELLO, Amalia, TUMINO, Rosario, GRASSO, Chiara, ONLAND-MORET, N. charlotte, WEIDERPASS, Elisabete, QUIRÓS, José ramón, LUJÁN BARROSO, Leila, RODRÍGUEZ BARRANCO, Miguel, COLORADO-YOHAR, Sandra, BARRICARTE, Aurelio, DORRONSORO, Miren, IDAHL, Annika, LUNDIN, Eva, SARTOR, Hanna, KHAW, Kay-tee, KEY, Timothy j., MULLER, David c., RIBOLI, Elio, GUNTER, Marc j., DOSSUS, Lauren, KAAKS, Rudolf. Predicting circulating CA125 levels among healthy premenopausal women. _Cancer Epidemiology Biomarkers & Prevention_. 2019. Vol. 28, núm. 6. [consulta: 1 de febrer de 2026]. ISSN: 1055-9965. [Disponible a: https://hdl.handle.net/2445/174982]

Exportar metadades

JSON - METS

Compartir registre