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Loss of Visceral Fat is Associated with a Reduction in Inflammatory Status in Patients with Metabolic Syndrome
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Scope: Excessive visceral adipose tissue (VAT) is associated with higher secretion of pro-inflammatory molecules, contributing to systemic inflammation and obesity-related metabolic disturbances. Methods & results: This prospective analysis includes 117 overweight/obese adults (55-75 years) from the PREDIMED-Plus study. Fourteen inflammatory markers and adipokines were measured using a Bio-Plex assay with multiplex technology: insulin, glucagon, IL-6, visfatin, ghrelin, GLP-1, TNF-α, MCP-1, PAI-1, resistin, C-peptide, leptin, adipsin and adiponectin. Participants were categorized into tertiles according to changes in VAT after 1-year of follow-up, determined by dual-energy X-Ray absorptiometry. Participants allocated in tertile 3, which represent an increase of VAT content after 1-year of follow-up compared to tertile 1, showed significant differences in insulin (T3 versus T1, fully adjusted model: p = 0.037, p for trend 0.042), PAI-1 (fully adjusted model: p = 0.05, p for trend 0.06), c-peptide (fully adjusted model: p = 0.037, p for trend 0.042), and TNF-α (fully adjusted model p = 0.037, p for trend 0.042). Conclusion: Our results evidenced that a reduction in VAT was associated with clinical improvements in several inflammatory and adiposity markers, mainly in insulin, c-peptide, and PAI-1 levels, and these improvements may contribute to a reduction in cardiometabolic disturbances observed in obesity. This article is protected by copyright. All rights reserved. Keywords: Adipokines; Inflammation; Lifestyle; Mediterranean diet; Visceral adipose tissue.
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CASTRO-BARQUERO, Sara, CASAS RODRÍGUEZ, Rosa m., RIMM, Eric b., TRESSERRA I RIMBAU, Anna, ROMAGUERA, Dora, MARTÍNEZ HERNÁNDEZ, José alfredo, SALAS SALVADÓ, Jordi, MARTÍNEZ-GONZÁLEZ, Miguel ángel, VIDAL CORTADA, Josep, RUIZ CANELA, Miguel, KONIECZNA, Jadwiga, SACANELLA MESEGUER, Emilio, GARCÍA GAVILÁN, Jesús, FITÓ COLOMER, Montserrat, GARCÍA ARELLANO, Ana, ESTRUCH RIBA, Ramon. Loss of Visceral Fat is Associated with a Reduction in Inflammatory Status in Patients with Metabolic Syndrome. _Molecular Nutrition & Food Research_. 2023. Vol. 67. [consulta: 9 de abril de 2026]. ISSN: 1613-4125. [Disponible a: https://hdl.handle.net/2445/204562]