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Book part

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Published version

Publication date

2011

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/21371

Inhibitors of the M2 channel of influenza A virus

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http://hdl.handle.net/2445/32392

Abstract

Influenza is a highly contagious, major respiratory tract disease affecting millions of people each year. At present, two classes of antivirals are available: the neuraminidase inhibitors and the M2 proton channel blockers amantadine and rimantadine. However, rapid emergence of M2 blockers resistance makes imperative the development of new anti-influenza drugs. In the last few years several groups have synthesized and evaluated several analogs of amantadine. While several of them are active against wild-type M2 channel only a few are able to inhibit the mutant ion channels that lead to amantadine-resistance.

Description

Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32392

Subject

Influenzavirus, Resistència als medicaments, Inhibidors enzimàtics

Subject (English)

Influenza viruses, Drug resistance, Enzyme inhibitors

Citation

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Llibres / Capítols de llibre (Farmacologia, Toxicologia i Química Terapèutica)

Citation

DUQUE, María D., et al. Inhibitors of the M2 channel of influenza A virus. Recent Advances in Pharmaceutical Sciences. 2011. Vol.  Chapter 2, num. 35-64. [consulted: 9 of June of 2026]. Available at: https://hdl.handle.net/2445/21371

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