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2018-10-31

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cc-by (c) Mallorquí Bagué, Núria et al., 2018
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/157517

Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study

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https://doi.org/10.1038/s41598-018-33843-8

Resum

This study cross-sectionally examines in the elderly population: (a) the association of type 2 diabetes with executive function (EF); (b) the effect of BMI on both type 2 diabetes and EF; (c) the association between glycaemia control and EF in type 2 diabetes. 6823 older individuals with overweight/obesity and metabolic syndrome participating in the PREDIMED-PLUS study, were assessed with a battery of cognitive tests and a medical interview. ANOVA showed a significantly worse performance on EF in type 2 diabetes vs. non-diabetic individuals. Two complementary models were displayed: (1) in the whole sample, the presence of type 2 diabetes, depressive symptoms and BMI had a direct negative effect on EF, while apnoea had an indirect negative effect; (2) in the diabetes subsample, higher illness duration was associated with worse performance in EF. Participants with type 2 diabetes and HbA1c<53 mmol/mol displayed better cognitive performance when compared to those with HbA1c≥53 mmol/mol. Our results provide a controlled comprehensive model that integrates relevant neuropsychological and physical variables in type 2 diabetes. The model suggests that, to improve treatment adherence and quality of life once diabetes has been diagnosed, cognitive decline prevention strategies need to be implemented while monitoring depressive symptoms, BMI and glycaemia control.

Matèries

Diabetis, Obesitat, Persones grans, Malalties de les persones grans

Matèries (anglès)

Diabetes, Obesity, Older people, Older people diseases

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

MALLORQUÍ-BAGUÉ, Núria, LOZANO MADRID, María, TOLEDO ATUCHA, Estefanía, CORELLA PIQUER, Dolores, SALAS SALVADÓ, Jordi, CUENCA ROYO, Aida, VIOQUE, Jesús, ROMAGUERA, Dora, MARTÍNEZ, J. alfredo, WÄRNBERG, Julia, LÓPEZ MIRANDA, José, ESTRUCH RIBA, Ramon, BUENO CAVANILLAS, Aurora, ALONSO GÓMEZ, Ángel m., TUR, Josep antoni, TINAHONES, Francisco j., SERRA MAJEM, Lluís, MARTÍN SÁNCHEZ, Vicente, LAPETRA, José, VÁZQUEZ, Clotilde, PINTÓ SALA, Xavier, VIDAL I CORTADA, Josep, DAIMIEL, Lidia, GAFORIO, José j., MATÍA MARTÍN, Pilar, ROS RAHOLA, Emilio, GRANERO, Roser, BUIL COSIALES, Pilar, BARRAGÁN, Rocío, BULLÓ, Mònica, CASTAÑER, Olga, GARCÍA DE LA HERA, Manuela, YÁÑEZ, Aina m., ABETE, Itziar, GARCÍA RÍOS, Antonio, RUIZ CANELA, Miguel, DÍAZ LÓPEZ, Andrés, JIMÉNEZ-MURCIA, Susana, MARTÍNEZ-GONZÁLEZ, Miguel ángel, TORRE FORNELL, Rafael de la, FERNÁNDEZ ARANDA, Fernando. Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study. _Scientific Reports_. 2018. Vol. 8, núm. 1, pàgs. 16128. [consulta: 23 de gener de 2026]. ISSN: 2045-2322. [Disponible a: https://hdl.handle.net/2445/157517]

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