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720167.pdf (1.42 MB)

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2022-02-18

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cc-by (c) Gaviria, Lorena Patrícia et al., 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/183506

A descriptive analysis of urinary ESBL-Producing-Escherichia coli in Cerdanya Hospital

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Recurs relacionat

https://doi.org/10.3390/microorganisms10030488

Resum

Urinary tract infections caused by extended-spectrum β-lactamase Escherichia coli (ESBLEC) are increasing worldwide and are a current concern because treatment options are often limited. This study investigated antimicrobial susceptibility, antimicrobial resistance genes (ARGs), and the biological diversity of urinary ESBL-EC isolates at Cerdanya Hospital, a European cross-border hospital that combines French and Spanish healthcare models. Bacterial identification and susceptibility were determined using the Microscan WalkAway® system and ESBL production was examined by the double-disk synergy method. Isolates were sequenced using the Ion S5¿ next-generation sequencing system, with the whole-genome sequences then assembled using SPADEs software and analyzed using PubMLST, ResFinder, FimTyper, PlasmidFinder, and VirulenceFinder. A phylogenetic analysis was performed by constructing an assembly-based core-SNV alignment, followed by a phylogenetic tree constructed using Parsnp from the Harvest suite. All isolates studied were multidrug-resistant and could be classified into 19 different sequence types characterized by a high genetic diversity. The most prevalent ESBL-enzymes were CTX-M-14 and CTX-M-15. High-risk international clones (ST131, ST10, and ST405) were also identified. The results demonstrated the absence of a single predominant clone of ESBL-MDR-EC at Cerdanya Hospital.

Matèries

Escheríchia coli, Infeccions del tracte urinari, Resistència als medicaments

Matèries (anglès)

Escherichia coli, Urinary tract infections, Drug resistance

Citació

Col·leccions

Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Patologia i Terapèutica Experimental)

Citació

GAVIRIA, Lorena Patrícia, et al. A descriptive analysis of urinary ESBL-Producing-Escherichia coli in Cerdanya Hospital. Microorganisms. 2022. Vol. 10, num. 488. ISSN 2076-2607. [consulted: 16 of August of 2026]. Available at: https://hdl.handle.net/2445/183506

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