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2020-01-07

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/167458

Habitual Nut Exposure, Assessed by Dietary and Multiple Urinary Metabolomic Markers, and Cognitive Decline in Older Adults: The InCHIANTI Study.

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https://doi.org/10.1002/mnfr.201900532

Resum

Scope: The association between self-reported dietary intake and urinary metabolomic markers of habitual nut exposure with cognitive decline over a 3-year follow-up in an older Italian population is prospectively evaluated. Methods and results: A total of 119 older participants are selected, based on self-referred nut intake: the non-nut consumer (n = 72) and the regular consumer (≥2.9 g d-1 , n = 47). Nut exposure is measured at baseline either with the use of a validated food frequency questionnaire or with an HPLC-Q-ToF-MS metabolomic approach. Three years after, 28 from the nonconsumers and 10 from the consumers experienced cognitive decline. Dietary nut exposure is characterized by urinary metabolites of polyphenols and fatty acids pathways. Nut consumption estimated either by the dietary marker or by the urinary marker model is in both cases associated with less cognitive decline (OR: 0.78, 95% CI: 0.61,0.99; p = 0.043 and OR: 0.995, 95% CI: 0.991,0.999; p = 0.016, respectively) with AUCs 73.2 (95% CI: 62.9, 83.6) and 73.1 (62.5, 83.7), respectively. Conclusions: A high intake of nuts may protect older adults from cognitive decline. Metabolomics provides accurate and complementary information of the nut exposure and reinforces the results obtained using dietary information.

Matèries

Cuina (Nous), Cognició, Envelliment, Metabolòmica, Dietètica, Salut

Matèries (anglès)

Cooking (Nuts), Cognition, Aging, Metabolomics, Dietetics, Health

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Col·leccions

Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Institut de Recerca en Nutrició i Seguretat Alimentària (INSA·UB))

Citació

RABASSA BONET, Montserrat, ZAMORA-ROS, Raul, PALAU RODRÍGUEZ, Magalí, TULIPANI, Sara, MIÑARRO ALONSO, Antonio, BANDINELLI, Stefania, FERRUCCI, Luigi, CHERUBINI, Antonio, ANDRÉS LACUEVA, Ma. cristina. Habitual Nut Exposure, Assessed by Dietary and Multiple Urinary Metabolomic Markers, and Cognitive Decline in Older Adults: The InCHIANTI Study.. _Molecular Nutrition & Food Research_. 2020. Vol. 64, núm. 2, pàgs. e1900532. [consulta: 6 de febrer de 2026]. ISSN: 1613-4125. [Disponible a: https://hdl.handle.net/2445/167458]

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