Carregant...
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/180516
The TGF-β /NADPH Oxidases Axis in the Regulation of Liver Cell Biology in Health and Disease
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
The Transforming Growth Factor-beta (TGF-β) pathway plays essential roles in liver development and homeostasis and become a relevant factor involved in different liver pathologies, particularly fibrosis and cancer. The family of NADPH oxidases (NOXs) has emerged in recent years as targets of the TGF-β pathway mediating many of its effects on hepatocytes, stellate cells and macrophages. This review focuses on how the axis TGF-β/NOXs may regulate the biology of different liver cells and how this influences physiological situations, such as liver regeneration, and pathological circumstances, such as liver fibrosis and cancer. Finally, we discuss whether NOX inhibitors may be considered as potential therapeutic tools in liver diseases.
Matèries (anglès)
Citació
Citació
HERRANZ ITÚRBIDE, Macarena, PEÑUELAS HARO, Irene, ESPINOSA SOTELO, Rut, BERTRAN, Esther, FABREGAT, Isabel. The TGF-β /NADPH Oxidases Axis in the Regulation of Liver Cell Biology in Health and Disease. _Cells_. 2021. Vol. 10, núm. 9, pàgs. 2312. [consulta: 21 de gener de 2026]. ISSN: 2073-4409. [Disponible a: https://hdl.handle.net/2445/180516]