The TGF-β /NADPH Oxidases Axis in the Regulation of Liver Cell Biology in Health and Disease

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dc.contributor.authorHerranz Itúrbide, Macarena
dc.contributor.authorPeñuelas Haro, Irene
dc.contributor.authorEspinosa Sotelo, Rut
dc.contributor.authorBertran, Esther
dc.contributor.authorFabregat, Isabel
dc.date.accessioned2021-10-11T11:03:39Z
dc.date.available2021-10-11T11:03:39Z
dc.date.issued2021-09-03
dc.date.updated2021-10-07T07:26:31Z
dc.description.abstractThe Transforming Growth Factor-beta (TGF-β) pathway plays essential roles in liver development and homeostasis and become a relevant factor involved in different liver pathologies, particularly fibrosis and cancer. The family of NADPH oxidases (NOXs) has emerged in recent years as targets of the TGF-β pathway mediating many of its effects on hepatocytes, stellate cells and macrophages. This review focuses on how the axis TGF-β/NOXs may regulate the biology of different liver cells and how this influences physiological situations, such as liver regeneration, and pathological circumstances, such as liver fibrosis and cancer. Finally, we discuss whether NOX inhibitors may be considered as potential therapeutic tools in liver diseases.
dc.format.extent20 p.
dc.format.mimetypeapplication/pdf
dc.identifier.issn2073-4409
dc.identifier.pmid34571961
dc.identifier.urihttps://hdl.handle.net/2445/180516
dc.language.isoeng
dc.publisherMDPI AG
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.3390/cells10092312
dc.relation.ispartofCells, 2021, vol. 10, num. 9, p. 2312
dc.relation.urihttps://doi.org/10.3390/cells10092312
dc.rightscc by (c) Herranz Itúrbide, Macarena et al, 2021
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.sourceArticles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
dc.subject.classificationMalalties del fetge
dc.subject.classificationRegeneració (Biologia)
dc.subject.otherLiver diseases
dc.subject.otherRegeneration (Biology)
dc.titleThe TGF-β /NADPH Oxidases Axis in the Regulation of Liver Cell Biology in Health and Disease
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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