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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/147922
Intrinsically regulated learning is modulated by synaptic dopamine signaling
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We recently provided evidence that an intrinsic reward-related signal-triggered by successful learning in absence of any external feedback-modulated the entrance of new information into long-term memory via the activation of the dopaminergic midbrain, hippocampus, and ventral striatum (the SN/VTA-Hippocampal loop; Ripollés et al., 2016). Here, we used a double-blind, within-subject randomized pharmacological intervention to test whether this learning process is indeed dopamine-dependent. A group of healthy individuals completed three behavioral sessions of a language-learning task after the intake of different pharmacological treatments: a dopaminergic precursor, a dopamine receptor antagonist or a placebo. Results show that the pharmacological intervention modulated behavioral measures of both learning and pleasantness, inducing memory benefits after 24 hr only for those participants with a high sensitivity to reward. These results provide causal evidence for a dopamine-dependent mechanism instrumental in intrinsically regulated learning and further suggest that subject-specific reward sensitivity drastically alters learning success.
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RIPOLLÉS, Pablo, FERRERI, Laura, MAS-HERRERO, Ernest, ALICART, Helena, GÓMEZ ANDRÉS, Alba, MARCO PALLARÉS, Josep, ANTONIJOAN ARBÓS, Rosa ma. (rosa maría), NOESSELT, Toemme, VALLE, Marta, RIBA, Jordi, RODRÍGUEZ FORNELLS, Antoni. Intrinsically regulated learning is modulated by synaptic dopamine signaling. _eLife_. 2018. Vol. 7, núm. e38113. [consulta: 25 de febrer de 2026]. ISSN: 2050-084X. [Disponible a: https://hdl.handle.net/2445/147922]