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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/190412
Does Consumption of Ultra-Processed Foods Matter for Liver Health? Prospective Analysis among Older Adults with Metabolic Syndrome
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Non-alcoholic fatty liver disease (NAFLD) includes a spectrum of liver alterations that can result in severe disease and even death. Consumption of ultra-processed foods (UPF) has been associated with obesity and related comorbidities. However, the link between UPF and NAFLD has not been sufficiently assessed. We aimed to investigate the prospective association between UPF consumption and liver health biomarkers. Methods: We followed for 1 year 5867 older participants with overweight/obesity and metabolic syndrome (MetS) from the PREDIMED-Plus trial. A validated 143-item semi-quantitative food frequency questionnaire was used to evaluate consumption of UPF at baseline, 6, and 12 months. The degree of processing for foods and beverages (g/day) was established according to the NOVA classification system. The non-invasive fatty liver index (FLI) and hepatic steatosis index (HSI) were used to evaluate liver health at three points in time. The associations between changes in UPF consumption (percentage of total daily dietary intake (g)) and liver biomarkers were assessed using mixed-effects linear models with repeated measurements. Results: In this cohort, UPF consumption at baseline was 8.19% (SD 6.95%) of total daily dietary intake in grams. In multivariable models, each 10% daily increment in UPF consumption in 1 year was associated with significantly greater FLI (β 1.60 points, 95% CI 1.24;1.96 points) and HSI (0.43, 0.29; 0.57) scores (all p-values < 0.001). These associations persisted statistically significant after adjusting for potential dietary confounders and NAFLD risk factors. Conclusions: A higher UPF consumption was associated with higher levels of NAFLD-related biomarkers in older adults with overweight/obesity and MetS.
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KONIECZNA, Jadwiga, FIOL SALA, Miguel, COLOM, Antoni, MARTÍNEZ-GONZÁLEZ, Miguel ángel, SALAS SALVADÓ, Jordi, CORELLA PIQUER, Dolores, SORIA FLORIDO, María trinidad, MARTÍNEZ, J. alfredo, ALONSO GÓMEZ, Ángel m., WÄRNBERG, Julia, VIOQUE, Jesús, LÓPEZ MIRANDA, José, ESTRUCH RIBA, Ramon, BERNAL LÓPEZ, M. rosa, LAPETRA, José, SERRA MAJEM, Lluís, BUENO CAVANILLAS, Aurora, TUR, Josep antoni, MARTÍN SÁNCHEZ, Vicente, PINTÓ SALA, Xavier, GAFORIO, José j., MATÍA MARTÍN, Pilar, VIDAL I CORTADA, Josep, VÁZQUEZ, Clotilde, DAIMIEL, Lidia, ROS RAHOLA, Emilio, BES RASTROLLO, Maira, PASCUAL, Maria, SORLÍ, José v., GODAY ARNÓ, Albert, ZULET, M. angeles, MORENO RODRIGUEZ, Anai, CARMONA GONZÁLEZ, Francisco jesús, VALLS ENGUIX, Rafael, JANER, Juana m., GARCIA-RIOS, Antonio, CASAS RODRÍGUEZ, Rosa m., GÓMEZ PÉREZ, Ana maría, SANTOS LOZANO, Jose manuel, BASTERRA GORTARI, F. javier, MARTÍNEZ, María ángeles, ORTEGA AZORÍN, Carolina, BAYÓ I LLIBRE, Joan, ABETE, Itziar, SALAVERRIA LETE, Itziar, RUIZ CANELA, Miguel, BABIO, Nancy, CARRES, Lourdes, ROMAGUERA, Dora. Does Consumption of Ultra-Processed Foods Matter for Liver Health? Prospective Analysis among Older Adults with Metabolic Syndrome. _Nutrients_. 2022. Vol. 14, núm. 19, pàgs. 4142. [consulta: 21 de gener de 2026]. ISSN: 2072-6643. [Disponible a: https://hdl.handle.net/2445/190412]