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2023-05-01

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cc by-nc-nd (c) Vargas, Ronny et al., 2023
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/200887

Dialysis is a key factor modulating interactions between critical process parameters during the microfluidic preparation of lipid nanoparticles

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https://doi.org/10.1016/j.colcom.2023.100709

Abstract

Manufacturing lipid nanoparticles through microfluidic mixing can be approached from a Quality by Design perspective. Research involving critical process parameters seems to focus on the total flow and flow rate ratio, thus other process variables, such as dialysis, are underestimated. This study used a Design of Experiments to identify the influence of critical process parameters on particle size, polydispersity index, and zeta potential. A response surface Design of Experiments modeled the influence of: total flow (400 to 4000 mu L min-1); flow rate ratio (3 to 9) and dialysis (yes/no). Results suggest that dialysis is a crucial parameter that strongly influences particle size and zeta potential and moderately affects polydispersity index. The flow rate ratio's relevance decreases when dialysis is performed. As the purification method can change the influence of other process parameters, it should be an integrated part of the microfluidic manufacturing of lipid nanoparticles instead of an extra step.

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Disseny d'experiments, Nanopartícules, Tecnologia farmacèutica

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Experimental design, Nanoparticles, Pharmaceutical technology

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Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

VARGAS, Ronny, et al. Dialysis is a key factor modulating interactions between critical process parameters during the microfluidic preparation of lipid nanoparticles. Colloid and Interface Science Communications. 2023. Vol. 54, num. 100709. ISSN 2215-0382. [consulted: 18 of August of 2026]. Available at: https://hdl.handle.net/2445/200887

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